alexa Effect of Ethanolic Extract of Coconut (Cocos nucifera)
ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Effect of Ethanolic Extract of Coconut (Cocos nucifera) on Aspirin-induced Gastric Ulcer in Albino Rats

Amjad M* and Tahir M

Department of Anatomy, Avicenna Medical College, Lahore, Pakistan

*Corresponding Author:
Amjad Mcorr
Department of Anatomy, Avicenna Medical College
Phase IX, DHA, Bedian Road, 53100, Lahore, Pakistan
Tel: 042 37167566
Email: [email protected]

Received date: March 28, 2017; Accepted date: June 20, 2017; Published date: June 27, 2017

Citation: Amjad M, Tahir M (2017) Effect of Ethanolic Extract of Coconut (Cocos nucifera) on Aspirin-induced Gastric Ulcer in Albino Rats. J Gastrointest Dig Syst 7:512. doi: 10.4172/2161-069X.1000512

Copyright: © 2017 Amjad M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Statement of problem: Aspirin is extensively used as an analgesic, antipyretic, anti-thrombotic and antiinflammatory drug. It is safe in therapeutic doses but it is toxic in over dosage or in chronic injudicious use, when it causes acute or chronic toxicity respectively. Acute toxicity causes gastric ulceration and bleeding. Gastric ulcer developed when the imbalance occurs between aggressive and defensive factors of the stomach and situation favours aggressive factors enough to cause mucosal damage and lead to ulceration. Many antioxidants have been trying to study their protective effects of aspirin and others NSAID’s induced gastric ulcers. Coconut and its products are known for their antioxidant, antibacterial, anti-diabetic, antithrombotic and antiulcer genic effects. Two different studies are documented about the effect of ethanolic extract of coconut on indomethacin induced gastric ulcers. Both are paradoxical, and show controversy at different doses of extract. The present study, therefore, designed in an attempt to observe the effects of high doses of ethanolic extract of coconut on aspirin induced gastric ulcers. This was conducted at University of Health Sciences Lahore. Thirty rats, weighing 175-220 gm, were divided into six groups and were treated with different doses of extract for 14 days and were sacrificed on 15th day of experiment. Methodology involved staining of stomach with H and E and Masson Trichome staining and was observed for desquamation, mucosal congestion, inflammatory Cells and necrosis. Blood samples were drawn for serum analysis of Super Oxide Dismutase (SOD).

Findings: The results showed that ethanolic extract of coconut helps to heal the stomach ulcers and gives best results at 400 mg/kg dose and also helps to reduce oxidative stress which also helps to heal ulcers.

Conclusion and significance: It was concluded that ethanolic extract of coconut provides a very reliable and cost effective adjunctive therapy to be routinely used in patients who take aspirin and aspirin induced gastric ulcers as well.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords