Effect of RBD Mutation (Y453F) in Spike Glycoprotein of SARS-CoV-2 on Neutralizing Antibody Affinity
Received Date: Jan 18, 2021 / Accepted Date: Feb 01, 2021 / Published Date: Feb 08, 2021
Abstract
Background: Infection with Receptor-Binding Domain (RBD) mutant (Y453F) of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) from farmed minks is known to widely spread among humans.
Methods: We investigated the characteristics of SARS-CoV-2 RBD Y453F mutant using three-dimensional structural analysis. We investigated the effect of the RBD Y453F mutant of SARS-CoV-2 on neutralizing antibodies in serum derived from Coronavirus Disease 2019 (COVID-19) positive patients.
Results: Our studies suggest that virus variants with RBD Y453F mutation partially escaped detection by four neutralizing monoclonal antibodies and neutralizing antibodies in serum.
Conclusion: Consequently, raising concern that infection of SARS-CoV-2 mutants that cause serious symptoms in humans may spread globally.
Keywords: RBD Y453F mutant; Neutralizing antibody; SARS-CoV-2; COVID-19
Citation: Hayashi T, Yaegashi N, Konishi I (2021) Effect of RBD Mutation (Y453F) in Spike Glycoprotein of SARS-CoV-2 on Neutralizing Antibody Affinity. Diagnos Pathol Open 6: 181. Doi: 10.4172/2476-2024.1000181
Copyright: © 2021 Hayashi T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Share This Article
Open Access Journals
Article Tools
Article Usage
- Total views: 1333
- [From(publication date): 0-2021 - May 19, 2024]
- Breakdown by view type
- HTML page views: 783
- PDF downloads: 550
