alexa Effect of Yokukansan, a Traditional Herbal Prescription, on Sle ep Disturbances in Patients with Alzheimer's Disease | OMICS International | Abstract
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
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Research Article

Effect of Yokukansan, a Traditional Herbal Prescription, on Sle ep Disturbances in Patients with Alzheimer's Disease

Hideto Shinno1*, Ichiro Ishikawa2, Nobuo Ando2, Jun Horiguchi3, and Yu Nakamura2

1Department of Liaison Psychiatry, Kagawa University School of Medicine, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan

2Department of Neuropsychiatry, Kagawa University School of Medicine, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan

3Department of Psychiatry, Shimane University Faculty of Medicine, 85-1 Enya, Izumo, Shimane 693-8501, Japan

Corresponding Author:
Hideto Shinno, Professor
Department of Liaison Psychiatry
Kagawa University School of Medicine
1750-1 Ikenobe, Miki, Kita
Kagawa 761- 0793, Japan
Tel: +81-87-891-2165
E-mail: [email protected]

Received date: January 27, 2016; Accepted date: February 29, 2016; Published date: March 07, 2016

Citation: Shinno H, Ishikawa I, Ando N, Horiguchi J, Nakamura Y (2016) Effect of Yokukansan, a Traditional Herbal Prescription, on Sleep Disturbances in Patients with Alzheimer’s Disease. J Alzheimers Dis Parkinsonism 6:215. doi:10.4172/2161-0460.1000215

Copyright: © 2016 Shinno H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective: Evidence of the effects of Yokukansan (YKS), a traditional herbal medicine, on behavioral and psychological symptoms of dementia (BPSD) has accumulated. As well as BPSD, patients with Alzheimer’s disease (AD) demonstrate poorer sleep quality. Specific sleep disorders such as sleep-disordered breathing and periodic limb movement disorder (PLMD) can be prevalent in the elderly. PLMs are generally considered to produce sleep fragmentation by provoking arousals. This study aimed to examine whether YKS alters polysomnography variables in patients with AD.

Methods: Seven patients (3 men and 4 women) with probable AD according to the standard criteria were investigated. Participants were treated with YKS for 4 weeks. The Neuropsychiatric Inventory for the assessment of BPSD, the Mini-Mental State Examination (MMSE) for cognitive function, polysomnography for evaluation of sleep structure and Pittsburgh Sleep Quality Index (PSQI) for subjective sleep quality, and Epworth Sleepiness Scale (ESS) were carried out at baseline and at the end of the treatment. The local institutional review boards approved this study. All patients gave written consent according to institutional guidelines and the tenets of the Declaration of Helsinki.

Results: Treatment with YKS resulted in a decreased NPI score, a prolonged total sleep time, a shortened sleep latency, an increased sleep efficiency, and decreased periodic limb movement during sleep. YKS also improved subjective evaluations with PSQI and ESS.

Conclusions: YKS was effective for BPSD and sleep disturbances in patients with AD. YKS did not induce daytime somnolence, extrapyramidal signs, or an increased apnea-hypopnea index.


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