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ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
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  • Research Article   
  • J Alzheimers Dis Parkinsonism 2018, Vol 8(1): 419
  • DOI: 10.4172/2161-0460.1000419

Effects of Plasmalogen on Patients with Mild Cognitive Impairment: A Randomized, Placebo-Controlled Trial in Japan

Takehiko Fujino1*, Tatsuo Yamada2, Takashi Asada3, Midori Ichimaru4, Yoshio Tsuboi5, Chikako Wakana6 and Shiro Mawatari1
1Institute of Rheological Functions of Food, 2241-1 Kubara, , Hisayama-machi, Kasuya-gun, Fukuoka 811-2501, Japan
2Gotanda Rehabilitation Hospital, , 8-8-20 Nishigotanda, Shinagawa-ku, Tokyo 141-0031, Japan
3Memory Clinic Ochanomizu, 1-5-34, Yushima, Bunkyo-ku, Tokyo 113-0034, , Japan
4BOOCS Holistic Clinic Tokyo, 3-4-1 Ginza, Chuo-ku, Tokyo 104-0061, , Japan
5Department of Neurology, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan
6BOOCS Clinic Fukuoka, , 6-18 Tenya-machi, Hakata-ku, Fukuoka 812-0025, Japan
*Corresponding Author : Takehiko Fujino, Institute of Rheological Functions of Food, 2241-1 Kubara, Hisayama-machi, Kasuya-gun, Fukuoka 811-2501, Japan, Tel: +81 92 273 2420, Email: [email protected]

Received Date: Jan 06, 2018 / Accepted Date: Jan 15, 2018 / Published Date: Jan 22, 2018

Abstract

Objective: It has been shown that plasmalogens (Pls) in the brain tissue and blood decrease among Alzheimer’s disease (AD) patients. We first confirmed the effects of Pls on animal AD models, and subsequently reported that the ingestion of 1 mg Pls was effective for AD patients in a randomized, placebo-controlled trial with mild cognitive impairment (MCI) or mild AD patients. The present study examined the efficacy of orally administered Pls on patients with MCI enrolled in the previous trial in terms of individual domains of the Mini Mental State Examination-Japanese (MMSE-J).

Methods: The present analysis used 178 patients with MCI out of the 276 patients with either MCI or AD in the previously reported trial, and assessed the 24 week change in the domain-specific scores of the MMSE-J. Originally, the randomized, placebo-controlled trial was performed for 276 patients at age of 60-85 years who had the MMSE-J score of 20-27 points and the Geriatric Depression Scale-Short Version-Japanese Version (GDS-S-J) score of 5 points or less. The patients were randomly allocated to either a treatment with 1 mg of scallop-derived Pls daily or a placebo treatment. The primary outcome was a 24 week change in the MMSE-J. The registered number of the trial is UMIN000014945.

Results: The MMSE-J total score improved statistically significantly in the Pls treatment but not in the placebo treatment, resulting in no significant between-treatment difference. With respect to one of the MMSE-J domains, orientation to place, the Pls treatment showed a significant improvement and the placebo treatment showed no such improvement; the between-treatment difference was statistically significant (p=0.003). The domain for orientation to time worsened significantly at endpoint in the placebo treatment, while the Pls treatment showed no worsening. However, the between-treatment difference failed to reach the statistical significance. No significant change was found in either treatment regarding the other MMSE-J domains.

Conclusion: These findings suggest that oral administration of 1 mg Pls enhances cognitive function of MCI patients, especially orientation to place.

Keywords: Mild cognitive impairment; Alzheimer’s disease; Plasmalogen; Mini mental state examination; Orientation to place

Citation: Fujino T, Yamada T, Asada T, Ichimaru M, Tsuboi Y, et al. (2018) Effects of Plasmalogen on Patients with Mild Cognitive Impairment: A Randomized, Placebo- Controlled Trial in Japan. J Alzheimers Dis Parkinsonism 8: 419. Doi: 10.4172/2161-0460.1000419

Copyright: ©2018 Fujino T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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