alexa Efficacy of Artesunate Plus Amodiaquine for Treatment of Uncomplicated Clinical Falciparum Malaria in Severely Malnourished Children Aged 6?59 Months, Democratic Republic of Congo | Abstract
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Special Issue Article

Efficacy of Artesunate Plus Amodiaquine for Treatment of Uncomplicated Clinical Falciparum Malaria in Severely Malnourished Children Aged 6?59 Months, Democratic Republic of Congo

P. Mitangala Ndeba1*, U. D’Alessandro2, P. Hennart3,5, P. Donnen3,5, D. Porignon4, G. Bisimwa Balaluka5,6, A. Bisimwa Nkemba6, N Cobohwa Mbiribindi6 and M. Dramaix Wilmet1,5

1Centre de recherche: épidémiologie, Biostatistique et recherche clinique, Ecole de Santé Publique, Université Libre de Bruxelles (Belgique)

2Department of Parasitology, Institute Tropical Medicine, Antwerp, Belgium

3Centre de recherche : épidémiologie et médecine préventive, Ecole de santé Publique, Université Libre de Bruxelles (Belgique)

4Unité de santé internationale, Département des Sciences de la Santé Publique, Université de Liège (Belgique).

5Centre Scientifique et Médical de l’Université Libre de Bruxelles pour ses Activités de Coopération (CEMUBAC)

6Département de nutrition, Centre de Recherche en Sciences Naturelles / Lwiro (République Démocratique du Congo)

*Corresponding Author:
Mitangala Ndeba Prudence
Centre de recherche: épidémiologie, biostatistique et recherche clinique
Ecole de Santé Publique, Université Libre de Bruxelles
CP 598, Route de Lennik 808, 1070 Bruxelles
Tel: +243 998 088 072
E-mail: [email protected]

Received Date: January 01, 2012; Accepted Date: April 21, 2012; Published Date: April 23, 2012

Citation: Ndeba PM, D’Alessandro U, Hennart P, Donnen P, Porignon D, et al. (2012) Efficacy of Artesunate Plus Amodiaquine for Treatment of Uncomplicated Clinical Falciparum Malaria in Severely Malnourished Children Aged 6–59 Months, Democratic Republic of Congo. J Clin Exp Pathol S3:005. doi: 10.4172/2161-0681.S3-005

Copyright: © 2012 Ndeba PM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Recent published studies on efficacy and safety of antimalarial treatment in children with Severe
Acute Malnutrition (SAM) suffering from uncomplicated malaria are not available.
Methods: Between March 2007 and December 2010 the efficacy of AS+AQ in treating uncomplicated malaria
children under five with SAM was carried out in Lwiro (Eastern Republic Democratic of Congo) according to the WHO
standard protocol. Among the 445 children included, 69 had SAM. AS+AQ was given according to national protocol.
Analysis was done using per protocol method. Odds ratio (OR) and their 95% confidence interval (95% CI) were
Results: The treatment failure rate was 24.4% of 414 infections included in the analysis. After adjustment for
malaria parasitemia, ACPR in children without SAM were 73.0% when it was 91.4% among those with SAM (OR
3.15 95%CI 1.19 – 8.30). Malaria parasitemia median at admission was statistically low among children who had
subsequently Adequate Clinical and Parasitological Response (ACPR).
Conclusion: AS+AQ has a good efficacy among children with both uncomplicated falciparum malaria and
malnutrition including severe acute form. AS+AQ dosing national strategy unmodified can be used, to treat under five
children with malnutrition including severe acute form suffering from uncomplicated malaria.


Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A


[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


porn sex

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

Gaziantep Escort

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A


[email protected]

1-702-714-7001Extn: 9037


James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

mp3 indir

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals


Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T


[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version