alexa

GET THE APP

Evaluation of Fluoride-18-Labeled Boronophenylalanine-Positron Emission Tomography Imaging for the Assessment of Boron Neutron Capture Therapy in Patients with Recurrent Head and Neck Squamous Cell Carcinoma| Abstract
ISSN: 2161-119X

Otolaryngology: Open Access
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Mini Review   
  • Otolaryngol (Sunnyvale) 2016, Vol 6(6): 277
  • DOI: 10.4172/2161-119X.1000277

Evaluation of Fluoride-18-Labeled Boronophenylalanine-Positron Emission Tomography Imaging for the Assessment of Boron Neutron Capture Therapy in Patients with Recurrent Head and Neck Squamous Cell Carcinoma

Teruhito Aihara1,2*, Jyunichi Hiratsuka3, Nobuyoshi Fukumitsu1, Hitoshi Ishikawa1, Norimasa Morita2, Hiroaki Kumada1, Nobuhiko Kamitani3, Kayoko Ohnishi1, Minoru Suzuki4, Hideyuki Sakurai1 and Tamotsu Harada2
1Proton Medical Research Centre, University of Tsukuba, , Tsukuba, Japan
2Department of Otolaryngology Head and Neck Surgery, Kawasaki Medical School, , Kurashiki, Japan
3Department of Radiation Oncology, Kawasaki Medical School, Kurashiki, , Japan
4Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Osaka, , Japan
*Corresponding Author : Teruhito Aihara M.D., Proton Medical Research Centre, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki, 305-8575, Japan, Tel: (+81)29-853-7100, Fax: (+81)29-853-7102, Email: [email protected]

Received Date: Oct 25, 2016 / Accepted Date: Nov 03, 2016 / Published Date: Nov 10, 2016

Abstract

Introduction: A role for fluoride-18-labeled boronophenylalanine positron emission tomography (18FBPA-PET) in boron neutron capture therapy (BNCT) has not been fully elucidated. We investigated the role of 18FBPA-PET in BNCT for recurrent head and neck squamous cell carcinoma (HNSCC) patients. Materials and methods: 18FBPA-PET images were obtained from 10 histologically verified recurrent HNSCC patients who received BNCT. The intratumoral accumulation of 18FBPA was calculated as the ratio of maximum and minimum radioactivity counts to that of normal tissue (Tmax/N and Tmin/N ratios, respectively). The percentage volume at which the radioactivity count ratio was >2.5 compared to normal tissue was also calculated (Vo2.5). Moreover, mean and minimum irradiation dose to the tumor was calculated. We investigated which parameters could predict the treatment effect of BNCT. Results: Treatment effects of local lesions were as follows: complete remission (CR) in 5 cases and non-CR in 5 cases. Only Tmin/N ratio showed a significant difference between the CR and non-CR groups (P=0.008). Conclusion: The Tmin/N ratio of 18FBPA-PET can predict the treatment effect of BNCT for recurrent HNSCC.

Keywords: Recurrence head and neck SCC; BNCT; 18FBPA-PET; T/N ratio; 10B

Citation: Aihara T, Hiratsuka J, Fukumitsu N, Ishikawa H, Morita N, et al. (2016) Evaluation of Fluoride-18-Labeled Boronophenylalanine-Positron Emission Tomography Imaging for the Assessment of Boron Neutron Capture Therapy in Patients with Recurrent Head and Neck Squamous Cell Carcinoma. Otolaryngol (Sunnyvale) 6:277. Doi: 10.4172/2161-119X.1000277

Copyright: ©2016 Aihara T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Recommended Conferences

7th European Otolaryngology-ENT Surgery Conference

Vienna, Austria
Article Usage
  • Total views: 2590
  • [From(publication date): 0-2016 - Oct 26, 2021]
  • Breakdown by view type
  • HTML page views: 2237
  • PDF downloads: 353
Top