Evaluation of the Hepatotoxic and Nephrotoxic Potential of Ethanolic Stem Back Extract of Xylopia Aethiopica (Annonaceae) in Male Rodents
Received Date: Feb 15, 2018 / Accepted Date: Apr 20, 2018 / Published Date: Apr 25, 2018
Abstract
Ethno pharmacological relevance: People in Nigeria and all over the world, use this plant preparations, for various therapeutic purposes, in folklore medicine. The aim of the study is to obtain the sub chronic nephrotoxic and hepatotoxic information on this plant.
Aim of study: Obtain nephrotoxic and hepatotoxic information regarding traditional use of plants.
Materials and methods: 32 male rats were grouped into 4 groups i.e. Group I (had no treatment), Group II (200 mg/kg body weight of extract), Group III (400 mg/kg body weight of extract) and Group IV (800 mg/kg body weight of extract) for a period of 28 days. On 14th and 28th day, three rats were sacrificed in each group and blood samples were obtained for kidney and hepatic function tests.
Result: It showed that there was a significant increase in weight, p<0.01 in Group III, but p<0.05. There was no significant effect on the kidney function parameters except for Urea at 200 and 400 mg/kg. Liver function tests, showed that ALP, AST and ALT were significantly reduced, p<0.001 compared to the control
Conclusion: It is possible therefore, to infer that the sub chronic toxicity study of X. aethiopica stem on liver and kidney has a toxic potential at high doses as it showed significant differences on some biomarkers of the kidney and liver functions. Moreover, the photomicrograph showed some slight histological alterations in both organs.
Citation: Ehigiator BE, Ezeani DN (2018) Evaluation of the Hepatotoxic and Nephrotoxic Potential of Ethanolic Stem Back Extract of Xylopia Aethiopica (Annonaceae) in Male Rodents. Diagn Pathol Open 3: 138. Doi: 10.4172/2476-2024.1000138
Copyright: © 2018 Ehigiator BE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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