Failure to develop Tolerance to Thyroid Peroxidase at an Early Age and a Strong Ctla-4 Gene Association Define Female-Dominated Type 1 Diabetes Subgroup
Received Date: Mar 02, 2023 / Published Date: Mar 30, 2023
Abstract
Type 1 diabetes and autoimmune thyroid disease (AITD) have been linked to HLA haplotypes with allelic variation of the T cell activation gene PTPN22 and the T cell regulatory gene CTLA4. We compare the relationship between these loci and type 1 diabetes patients with and without thyroid peroxidase autoantibodies (TPOAbs), an indicator of thyroid autoimmunity. People with type 1 diabetes from all over Great Britain had their TPOAbs measured. 67% were under the age of 18. Genotyping was done on these cases and controls from the same area.
Citation: Durrell P (2023) Failure to develop Tolerance to Thyroid Peroxidase at anEarly Age and a Strong Ctla-4 Gene Association Define Female-Dominated Type1 Diabetes Subgroup. J Clin Diabetes 7: 167.
Copyright: © 2023 Durrell P. This is an open-access article distributed under theterms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.
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