alexa
Reach Us +1-218-451-2974
Fat-1 Transgenic Mice: An Endogenous N-3 Polyunsaturated Fatty Acids Mouse Model is used in AD Research | OMICS International | Abstract
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Mini Review

Fat-1 Transgenic Mice: An Endogenous N-3 Polyunsaturated Fatty Acids Mouse Model is used in AD Research

Xiang Gao1, Yuhong Gan2, Kefeng Wu2, Wende Li2,3* and Ren Huang3

1Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China

2Guangdong Key Laboratory for Research and Development of Natural Drug, Guangdong Medical College, Zhanjiang, Guangdong, China

3Guangdong Key Laboratory of Animal, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China

4† Equal contributors

*Corresponding Author:
Wende Li
Guangdong Key Laboratory for Research and Development of Natural Drug
Guangdong Medical College, Zhanjiang, Guangdong, China
Tel: 0759-2230067
E-mail: [email protected]

Received date September 18, 2016; Accepted date October 12, 2016; Published date October 19, 2016

Citation: Gao X, Gan Y, Wu K, Li W, Huang R (2016) Fat-1 Transgenic Mice: An Endogenous N-3 Polyunsaturated Fatty Acids Mouse Model is used in AD Research. J Alzheimers Dis Parkinsonism 6:272. doi:10.4172/2161-0460.1000272

Copyright: © 2016 Gao X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been wildly considered for positive effect of Alzheimer’s disease (AD). However, the intake of n-3 PUFAs is not encouraging to draw firm conclusion through preclinical and clinical research. The contribution of debate is derived from interference of dietary n-3 PUFAs, because of controlling the components and ratio of dietary PUFAs difficultly. In this context, transgenic fat-1 mouse that is capable of converting n-6 to n-3 fatty acids by feeding high n-6 PUFAs diet, leading to balance high n-3/n-6 PUFAs ratio, with increasing endogenous n-3 PUFAs and decreasing n-6 PUFAs in their organs and tissues. Thus, fat-1 mice is an ideal model to study the efficacy and mechanism of n-3 PUFAs in AD research, without the interference of the inevitable factors from dietary n-3 PUFAs. The fat-1 transgenic mice have become a useful tool for studying the potential benefit of endogenous n-3 PUFAs in behavior and neuromechanism of AD.

Keywords

Top