Febrile Syndrome as a First Clinical Manifestation of Wilson Disease
Marisol Galvez-Martínez, Alfredo I. Servín-Caamaño, Eduardo Pérez-Torres and Fátima Higuera-de la Tijera*
Liver Clinic from Gastroenterology Department, “Hospital General of México, Dr. Eduardo Liceaga”, Mexico City, Mexico
- *Corresponding Author:
- Fátima Higuera-de la Tijera
Liver Clinic from Gastroenterology Department
“Hospital General of México, Dr. Eduardo Liceaga”
Dr. Balmis 148, 06726, Mexico City, Mexico
E-mail: [email protected]
Received date: March 07, 2015; Accepted date: April 23, 2015; Published date: April 30, 2015
Citation: Galvez-Martínez M, Servín-Caamaño AI, Pérez-Torres E, Higuera-de la Tijera F (2015) Febrile Syndrome as a First Clinical Manifestation of Wilson Disease. J Gastrointest Dig Syst 5:282. doi:10.4172/2161-069X.1000282
Copyright: © 2015 Martinez MG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
Wilson disease (WD) is a rare autosomal recessive genetic disorder associated with copper metabolism. ATP7B protein function is reduced or absent. The classical clinical presentation with positivity for Kayser-Fleischer rings, neurological and hepatic manifestations is not the rule. About half of the patients presenting liver disease may have atypical clinical manifestations and do not possess two of the three classical criteria.
Presentation of case: A 36 year-old male with atypical WD clinical presentation characterized by febrile syndrome and jaundice as the predominant manifestations of the disease.