alexa Gastro-Entero-Pancreatic Neuroendocrine Tumors (GEP-Nets): A Review
ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
Open Access

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Review Article

Gastro-Entero-Pancreatic Neuroendocrine Tumors (GEP-Nets): A Review

Bruno Zilberstein1*, Björn LDM Brücher2,3, Brian Guilherme Marta Coimbra1, Carolos Eduardo Jacob1, Leandro Cardoso Barchi1, Hernique Giroud Joaquim1 and Ivan Ceccobello1

1Digestive Surgery Division, San Paulo University, Sao Paulo, Brazil

2INCORE, International Consortium of Research Excellence of the Theodor- Billroth-Academy®, Germany–Israel– Serbia-USA

3Bon Secours Cancer Institute, Richmond, VA, USA

Corresponding Author:
Bruno Zilberstein
Professor of Surgery, Digestive Surgery Division
San Paulo University, Sao Paulo, Brazil
Tel: +55-11-999408370
E-mail: [email protected]

Received Date: September 26, 2013; Accepted Date: November 28, 2013; Published Date: December 05, 2013

Citation: Zilberstein B, Brücher BLDM, Coimbra BGM, Jacob CE, Barchi LC, et al. (2013) Gastric Cancer: Aspects of Minimal Invasive Technique. J Gastroint Dig Syst 3:158. doi:10.4172/2161-069X.1000158

Copyright: © 2013 Zilberstein B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Introduction: The diagnosis of Gastro-entero-pancreatic Neuroendocrine Tumors (GEP-NETs) is currently a common event and it has showed the highest incidence of NETs. The majority of this lesion are well differentiated and with only a minority performing a malignant behavior. However, it poses a significant challenge to diagnosis especially for the assessment of the malignant potential of well differentiated types and many aspects of the management remain unclear and controversial. Recently, some new progresses of this disease have been put into clinical practice and some are still on trail.

Methods: We will present a review of GEP-NETs on classification, pathology, clinical manifestation, biomarkers, management and follow-up.

Conclusion: This review aims to provide some new understanding of pathologic classification and clinical diagnosis in GEP-NETs. On the basis of patients’ individual condition, comprehensive treatment options should be carried out to achieve a better therapeutic effect and improve the quality of life.


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