ISSN: 2161-119X

Otolaryngology: Open Access
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  • Case Report   
  • Otolaryngol (Sunnyvale) 2016, Vol 6(5): 262
  • DOI: 10.4172/2161-119X.1000262

Giant Cell Reparative Granuloma Presenting as Cheek Swelling: Case Series of Four Patients

Minakshi Gulia* and Neelam Sood
Department of Pathology, Deen Dayal Upadhyaya Hospital, New Delhi, , India
*Corresponding Author : Minakshi Gulia, Department of Pathology, Deen Dayal Upadhyaya Hospital, New Delhi, India, Tel: 919582110284, Email: mint.ucms@gmail.com

Received Date: Aug 05, 2016 / Accepted Date: Sep 08, 2016 / Published Date: Sep 15, 2016

Abstract

Giant cell reparative granuloma is a clinically distinctive intraosseous proliferation most commonly arising in mandible and maxilla. It is classified under fibro inflammatory reactive-reparative lesion. Histopathological features comprise of irregularly distributed multinucleated osteoclast like giant cells in a supporting fibrous stroma along with peripheral osteoid formation and stromal hemorrhage. All the four patients in this study had a characteristic clinicopathological presentation and immunohistochemistry. Differential diagnosis from other giant cell lesions of the bone, especially Giant cell tumor, was pivotal since GCT has a tendency for recurrence and a rare ability to undergo sarcomatous transformation or metastasis. Postoperative follow up of all the patients was unremarkable and there was no recurrence.

Keywords: Giant cell reparative granuloma (GCRG); Giant cell tumor (GCT); Vimentin; CD68; Immunohistochemistry (IHC)

Citation: Gulia M, Sood N (2016) Giant Cell Reparative Granuloma Presenting as Cheek Swelling: Case Series of Four Patients. Otolaryngol (Sunnyvale) 6:262. Doi: 10.4172/2161-119X.1000262

Copyright: ©2016 Gulia M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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