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Harmonized Collaborative Validation of a Simultaneous and Multiple Determination Method for Nivalenol, Deoxynivalenol, T-2 Toxin, HT-2 Toxin, and Zearalenone in Wheat and Barley by Liquid Chromatography Coupled to Tandem Mass Spectrometry (LC-MS/MS) | Abstract
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
Open Access

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Research Article

Harmonized Collaborative Validation of a Simultaneous and Multiple Determination Method for Nivalenol, Deoxynivalenol, T-2 Toxin, HT-2 Toxin, and Zearalenone in Wheat and Barley by Liquid Chromatography Coupled to Tandem Mass Spectrometry (LC-MS/MS)

Hiroyuki Nakagawa1*, Shigehiro Naito1, Yuusuke Kitani2, Yoshinao Ito2, Yoshikazu Aoyama3, Matsuhisa Koyama3, Yuusuke Hiejima4,Keisuke Nakamura4, Hiroshi Miyazaki5, Horie-Ishiguro Morita5, Masayoshi Tamura6, Naoki Mochizuki6, Masaru Nakamura7, Yuusuke Seki8, Hisae Kadokura9, Hidaka Ikeda10, Tomoko Horie-Ishiguro11, Yoriko Saito12, Miyoko Tajima12, Yohsuke Shigemasu13, Kikuko Kasama14, Yasuyo Oguma14, Yuki Sago1, Tetsuhisa Goto15 and Kazuyuki Hirayae16

1National Agriculture and Food Research Organization (NARO), National Food Research Institute (NFRI), 2-1-12 Kannon-dai, Tsukuba-shi, Ibaraki 305-8642, Japan

2Food and Agricultural Materials Inspection Center (FAMIC) Headquarters, Saitama, Japan

3Food and Agricultural Materials Inspection Center (FAMIC) Nagoya Regional Center, Aichi, Japan

4Food and Agricultural Materials Inspection Center (FAMIC) Kobe Regional Center, Hyogo, Japan

5Japan Grain Inspection Association, Tokyo Research Laboratory, Tokyo, Japan

6Asahi Group Holdings, Ltd., Research Laboratories for Food Safety Chemistry, Ibaraki, Japan

7Showa Sangyo Co., Ltd., Research & Development Center, Chiba, Japan

8Nisshin Seifun Group Inc., QE (quality exam.) Center, Saitama, Japan

9Kagome Co., Ltd., Research & Development Division Tochigi, Japan

10S&B Foods, Inc., Itabashi Spice Center, Tokyo, Japan

11NH Foods Ltd., R&D Center, Ibaraki, Japan

12Co-op net Business Association, Quality Control Department, Saitama, Japan

13National Federation of Agricultural Co-operative Associations, Central Research Institute for Feed and Livestock, Ibaraki, Japan

14Food and Drug Safety Center (FDSC), Hatano Research Institute (HRI), Kanagawa, Japan

15Shinshu University, Faculty of Agriculture, Nagano, Japan

16National Agriculture and Food Research Organization (NARO), National Agricultural Research Center for Kyushu Okinawa Region, Kumamoto, Japan

*Corresponding Author:
Hiroyuki Nakagawa
National Agriculture and Food Research Organization (NARO)
National Food Research Institute (NFRI)
2-1-12 Kannon-dai, Tsukuba-shi
Ibaraki 305-8642, Japan
Tel: +81-29-838-8085
Fax:+81-29-838-7996
E-mail: [email protected]

Received date: April 26, 2014; Accepted date: June 04, 2014; Published date: June 06, 2014

Citation: Nakagawa H, Naito S, Kitani Y, Ito Y, Aoyama Y, et al. (2014) Harmonized Collaborative Validation of a Simultaneous and Multiple Determination Method for Nivalenol, Deoxynivalenol, T-2 Toxin, HT-2 Toxin, and Zearalenone in Wheat and Barley by Liquid Chromatography Coupled to Tandem Mass Spectrometry (LCMS/ MS). J Anal Bioanal Techniques S6:002 doi: 10.4172/2155-9872.S6-002

Copyright: ©2014 Nakagawa H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Abstract

Harmonized collaborative validation of a simultaneous and multiple determination method for nivalenol, deoxynivalenol, T-2 toxin, HT-2 toxin, and zearalenone in wheat and barley by liquid chromatography tandem mass spectrometry (LC-MS/MS) was conducted by participants from 12 laboratories. The fortified samples of wheat and barley at three different levels and one naturally contaminated wheat sample were extracted, consecutively purified through a Presep C18 (ODS) solid phase extraction column and a Bond Elut Mycotoxin multifunctional column, and were analyzed by LC-MS/MS. The employment of internal standards (verrucarol and zearalanone) was apparently effective to ensure repeatability and reproducibility with sufficient recovery of each mycotoxin. This is the first report of the harmonized collaborative validation study of a simultaneous and multiple determination method for both type A and B trichothecenes along with zearalenone by LC-MS/MS. The validated method should be practical for monitoring of the major Fusarium mycotoxins contained in wheat and barley.

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