alexa Hereditary Gastrointestinal Polyposis Syndromes: A Revi
ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
Open Access

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Review Article

Hereditary Gastrointestinal Polyposis Syndromes: A Review Including Newly Identified Syndromes

Aaron Ryan Huber1*, Jennifer J Findeis-Hosey2 and Christa L Whitney-Miller2

1University of Rochester Medical Center, Surgical Pathology Unit, USA

2University of Rochester Medical Center, School of Medicine and Dentistry, Rochester, USA

Corresponding Author:
Aaron Ryan Huber
University of Rochester Medical Center
Surgical Pathology Unit
601 Elmwood Avenue
Rochester, NY 14618, USA
Tel: (585) 275-1702
Fax: (585) 276-2802
E-mail: [email protected]

Received Date: November 06, 2013; Accepted Date: November 21, 2013; Published Date: November 29, 2013

Citation: Huber AR, Findeis-Hosey JJ, Whitney-Miller CL (2013) Hereditary Gastrointestinal Polyposis Syndromes: A Review Including Newly Identified Syndromes J Gastroint Dig Syst 3:155. doi:10.4172/2161-069X.1000155

Copyright: © 2013 Huber AR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



There are multiple hereditary and non-hereditary polyposis syndromes that were originally categorized as adenomatous or hamartomatous. More recently, serrated polyps and their syndromes have been defined. Nearly all of these syndromes have a risk of colorectal cancer in the individuals and affected family members. Most of these syndromes are associated with extracolonic manifestations, including extracolonic tumors. The major clinical features, genetic mechanisms, and clinical management of Familial Adenomatous Polyposis (FAP), Peutz-Jeghers Syndrome (PJS), Juvenile Polyposis Syndrome (JPS), PTEN Hamartoma Syndrome (PTHS), and the more recently described syndromes MUTYH-Associated Polyposis, Hereditary Mixed Polyposis Syndrome, Serrated Polyposis Syndrome, and Polymerase Proofreading Associated Polyposis are summarized in this article.


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