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Histopathological Study of Acute Toxicity of Adonis Aestivalis (Summer Pheasant's Eye) in Rabbits | OMICS International | Abstract
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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Research Article

Histopathological Study of Acute Toxicity of Adonis Aestivalis (Summer Pheasant's Eye) in Rabbits

Rahim Hobbenaghi1, Javad Javanbakht2*, Moharam Kamrani3, Ali Bashiri Dezfouli4, Mehdi Aghamohammad Hassan5 and Mohammad Zamani2

1Departement of Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

2Department of Pathology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran

3Graduate student, Faculty Veterinary Medicine Urmia University, Urmia, Iran

4Graduate student, Faculty Veterinary Medicine Tehran University, Tehran, Iran

5Department of Clinical Science, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran

*Corresponding Author:
Dr. Javad Javanbakht
Department of Pathology
Faculty of Veterinary Medicine
Tehran University, Tehran, Iran
Tel: +989372512581
E-mail: [email protected]

Received Date: June 12, 2012; Accepted Date: August 14, 2012; Published Date: August 18, 2012

Citation: Hobbenaghi R, Javanbakht J, Kamrani M, Dezfouli AB, Hassan MA, et al. (2012) Histopathological Study of Acute Toxicity of Adonis Aestivalis (Summer Pheasant’s Eye) in Rabbits. J Clin Exp Pathol 2:124.doi: 10.4172/2161-0681.1000124

Copyright: © 2012 Hobbenaghi R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The aim of this study was to evaluate the acute toxicity of the hydroalcolic extract obtained from flowers and
leaves of A. aestivalis in New Zealand White rabbits. In this study Sixteen New Zealand White rabbits (weighing 1700-
2200 g) were tested for 14 days. The animals were randomly divided into 2 groups (treatment and control) which every
group contained 8 rabbits. A. aestivalis (summer pheasant’s eye) was collected over multiple years, under different
growing conditions, and at various stages of maturity, dried, and administered to rabbits to evaluate the toxicity of A.
aestivalis. On microscopic examination, Severe hemorrhage, myocardial degeneration and necrosis in cardiac cells,
severe congestion and swelling of hepatocytes in liver, spread interstitial alveolar edema, congestion of pulmonary
arteries, medial hyperplasia and emphysema in lungs, PVC (pre-vascular cuffing), chromatolysis, neurophagy and
focal gliosis in brain, severe swelling of tubular endothelial cells, congestion of glomeruli, hyaline casts and severe
tubular necrosis in kidney, papillary hyperplasia of mucus layer, and mucous secretions into the intestine lumen were
observed. No pathological were found in other organs as well. Although Adonis spp. contain cardiac glycosides,
cardiac lesions have not previously been described in laboratory animals associated with consumption of adonis, and
this is the first report of adonis toxicosis in Iran. Effectively, these results demonstrate the presence of acute toxicity
due to ip treatment with A. aestivalis for 14 days in New Zealand White rabbits. However, other toxicological studies
are necessary to evaluate the total.


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