alexa Human Papilloma Virus-Induced Head and Neck Cancer
ISSN: 2161-119X

Otolaryngology: Open Access
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Review Article

Human Papilloma Virus-Induced Head and Neck Cancer

Dennie V Jones1*, Houman Fekrazad M2 and Julie E Bauman3

1Division of Medical Oncology, University of Kentucky Markey Cancer Center, Lexington, KY, USA

2University of New Mexico Cancer Center, Albuquerque, NM, USA

3University of Pittsburgh Center Institute, Pittsburgh, PA, USA

Corresponding Author:
Dennie V. Jones
Division of Medical Oncology
University of Kentucky
800 Rose Street, Room CC412
Lexington, KY, USA 40536-0093
Tel: 859-257-2014
Fax: 859-257-7715
E-mail: [email protected]

Received date: December 04, 2012; Accepted date: December 29, 2012; Published January 03, 2013

Citation: Jones DV, Houman Fekrazad M, Bauman JE (2012) Human Papilloma Virus-Induced Head and Neck Cancer. Otolaryngology S2:002. doi:10.4172/2161-119X.S2-002

Copyright: © 2012 Jones DV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Head and neck cancers are a common spectrum of diseases, accounting for over one-third of a million deaths worldwide each year, and over 11,000 annual US deaths. Most head and neck cancers have traditionally been diagnosed in older males who abuse tobacco and/or alcohol. With increasing public awareness of the dangers of tobacco exposure and excessive alcohol intake, the incidence of many subgroups of head and neck cancer is now decreasing in the West. However, over the past several decades, the rates of carcinomas of the tonsil and base of tongue are increasing, and are affecting a different demographic group consisting mainly of younger, nonsmoking, males. These lesions are caused by infections with the same high-risk human papillomaviruses (HPV) genotypes as those responsible for cervical cancer and other anogenital neoplasms. These HPV-induced head and neck cancers differ in their biology and prognosis from those neoplasms induced by tobacco or ethanol. Understanding the biology of these lesions will allow for the development of selective preventive and treatment strategies, and better outcomes, for this subpopulation of patients.

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