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Human Papillomavirus Genotypes in Invasive Cervical Carcinoma in HIV Seropositive and Seronegative Women in Zimbabwe | OMICS International| Abstract
ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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  • Research Article   
  • J Infect Dis Ther 2017, Vol 5(6): 343
  • DOI: 10.4172/2332-0877.1000343

Human Papillomavirus Genotypes in Invasive Cervical Carcinoma in HIV Seropositive and Seronegative Women in Zimbabwe

Washington Mudini1*, Joel Michael Palefsky2, Martin John Hale3, Michael Zvavahera Chirenje4, Rudo Tanyaradzwa Makunike-Mutasa5, Fiona Mutisi6, Alltalents Murahwa7 and Mario Altini8
1Department of Anatomical Pathology, University of the Witwatersrand, Parktown, Johannesburg, Gauteng 2001, South Africa
2Department of Medicine, University of California San Francisco, USA
3Department of Anatomical Pathology, Faculty of Health Sciences, University of the Witwatersrand, National Health Laboratory Service, Johannesburg, South Africa
4Department of Obstetrics and Gynaecology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe
5Department of Histopathology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe
6University of Zimbabwe-University of California San Francisco Collaborative Research Program, University of Zimbabwe, Harare, Zimbabwe
7Department of Immunology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe
8Department of Anatomical Pathology, Faculty of Health Sciences, University of the Witwatersrand, South Africa
*Corresponding Author : Washington Mudini, Department of Anatomical Pathology, University of the Witwatersrand, Parktown, Johannesburg, Gauteng 2001, South Africa, Tel: +27 11 489 8720, Fax: +27 11 489 8512, Email: [email protected]

Received Date: Nov 14, 2017 / Accepted Date: Nov 24, 2017 / Published Date: Nov 27, 2017

Abstract

Background: Invasive cervical carcinoma (ICC) accounts for 23% of all cancer-related deaths in Zimbabwean women. Trials for a national program of genotype-specific HPV vaccines are underway to prevent cervical carcinoma, but the distribution of HPV types among women with ICC according to HIV status is unknown.
Methods: To determine prevalence and distribution of high-risk HPV genotypes by HIV status in women with ICC, we performed a cross-sectional study on women referred for ICC testing at four urban referral hospitals in Zimbabwe from June 2014-December 2015. Cervical biopsies were obtained for histology and HPV genotyping. HIV serology testing was performed. HPV testing was performed using MY09/MY11 PCR followed by typing using dot blot hybridization.
Results: Of 107 participants with histologically-proven, HIV prevalence was 49.5% (53/107). HIV-positive women tended to be younger (median age 44 years) than HIV-negative women (median age 59 years). HPV prevalence was 94% (101/107), ranging from 1-5 genotypes per participant. HPV 16 (81.5%), 18 (24%), 33 (13%), 35 (11%), 56 (9%) and 45(7.4%) were the most prevalent genotypes amongst HIV-negative participants; HPV 16 (67.9%), 18 (43.4%), 56 (18.9%), 45 (15.1%), 33 (11.3%), and 58 (9.4%) were most prevalent amongst HIV-positive participants. 83% of women were infected with either HPV-16 or HPV-18.
Conclusion: Effective vaccination programs against HPV 16 and 18 could prevent up to 83% of cases of cervical cancer in Zimbabwe. HIV may influence distribution of some HPV genotypes given the significant increase in prevalence of HPV 18 amongst HIV positive participants.

Keywords: HPV 16; HPV 18; HIV; Cervical cancer; Zimbabwe; Dot blot hybridization; HPV vaccine

Citation: Mudini W, Palefsky JM, Hale MJ, Chirenje MZ, Makunike-Mutasa RT, et al. (2017) Human Papillomavirus Genotypes in Invasive Cervical Carcinoma in HIV Seropositive and Seronegative Women in Zimbabwe. J Infect Dis Ther 5: 343. Doi: 10.4172/2332-0877.1000343

Copyright: © 2017 Mudini W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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