alexa Idiopathic Granulomatous Mastitis, a Clinicopathological Review of 22 Cases
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
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Research Article

Idiopathic Granulomatous Mastitis, a Clinicopathological Review of 22 Cases

Fariba Binesh1, Saied Kargar2, Shokouh Taghipour Zahir1, Nasim Behniafard3*, Hossein Navabi4 and Saied Arefanian4

1Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2Department of Surgery Shahid Sadoughi University of medical sciences, Yazd, Iran

3Researcher of Research and development Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

4General practitioner, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

*Corresponding Author:
Nasim Behniafard
Research and development Center
Shahid Sadoughi Hospital, Avicenna Blv
Safaeeh, Yazd, Iran
Tel: +983518113368
Fax: +983518224100
E-mail: [email protected]

Received Date: January 04, 2014; Accepted Date: January 29, 2014; Published Date: January 31, 2014

Citation: Binesh F, Kargar S, Zahir ST, Behniafard N, Navabi H, et al. (2014) Idiopathic Granulomatous Mastitis, a Clinicopathological Review of 22 Cases. J Clin Exp Pathol 4:157. doi: 10.4172/2161-0681.1000157

Copyright: © 2014 Binesh F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Idiopathic granulomatous mastitis is a rare chronic inflammatory disease and typically occurs in women at the reproductive life. The etiology, clinical course, and optimal treatment of this disorder remain obscure. The most common clinical presentation is a unilateral, firm, discrete breast mass, often associated with inflammation of the overlying skin. Because clinically the lesion can simulate carcinoma, definitive diagnosis is made using histopathology. The main purpose of this study was to present the clinicopathological features of patients with idiopathic granulomatous mastitis, as well as the authors’ experience with surgical treatment of these patients.
Methodology: The unit’s pathology database and clinic letters for the time period from January 2005 to May 2010 were used to identify patients who had presented with idiopathic granulomatous mastitis. Results: 22 female patients with a mean age of 35.14 ± 6.07 were included. The patients ranged in age from 24 to 44 years. All patients were parous, the median number of their pregnancies was 2 (ranging from 2 to 6) and the median duration of the last delivery was 4 years (ranging from 1.4 to 14 years).19 patients had a history of breast feeding. 8 patients (36.4%) had used hormonal contraception. The right breast was involved in 8 (36.4%) cases and in 12 (54.5%) patients; the left breast was affected. Erythema was the most common presenting symptom. Surgery was the definitive procedure in all patients. 13 patients (61.9%) presented with recurrence.
Conclusion: Increased recognition of this disease will improve its understanding and management of it. Longterm follow-up is necessary.


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