alexa
Reach Us +32-2-808-66-57
IL-10 restores MHC class I expression and interferes tumor immunity in papillary thyroid cancer with concomitant Hashimotos thyroiditis | OMICS International | Abstract
ISSN: 2476-2024

Diagnostic Pathology: Open Access
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

IL-10 restores MHC class I expression and interferes tumor immunity in papillary thyroid cancer with concomitant Hashimotos thyroiditis

Zhong-Wu Lu, Jia-Qian Hua, Li-Tao Han, Ting-Ting Zhang, Wen-Jun Wei, Yu-Long Wang, Yu Wang, Qing-Hai Ji and Tian Liao*
Department of Head and Neck Surgery, Fudan University, Shanghai,200032, China
*Corresponding Author: Tian Liao, Department of Head and Neck Surgery, Fudan University, Shanghai,200032, China, Tel: +86-021-64175590, Fax: 0086-021-64175590, Email: [email protected]

Received Date: Jul 18, 2019 / Accepted Date: Aug 01, 2019 / Published Date: Aug 12, 2019

Citation: Lu ZW, Hua JQ, Han LT, Zhang TT, Wei WJ, et al. (2019) IL-10 Restores MHC Class I Expression and Interferes Tumor Immunity in Papillary Thyroid Cancer with Concomitant Hashimoto’s Thyroiditis. Diagn Pathol Open 4: 152.

Copyright: © 2019 Lu ZW, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 
To read the full article Peer-reviewed Article PDF image

Abstract

Purpose: The incidence of papillary thyroid cancer (PTC) with concomitant Hashimoto’s thyroiditis (HT) is increasing. Interleukin-10 (IL-10) is a cytokine previously reported to be elevated in this condition. Evidence from multiple human malignancies showed IL-10 participated in tumor immunity and exhibited therapeutic potential. The aim of this study is to investigate whether IL-10 interferes tumor immunity in PTC with concomitant HT.

Method: Expression of IL-10 and major histocompatibility complex (MHC) class I were compared on PTC tissues with or without concomitant HT. PTC cell lines K1 and TPC-1 were stimulated with IL-10 and analyzed for MHC class I expression afterwards. T cell activation, production of Interleukin-2 (IL-2) and IFN-γ and programmed death-1 (PD-1) expression were assessed by coculture of donor peripheral blood lymphocytes (PBLs) with IL-10 pretreated PTC cells. Programmed death-ligand 1 (PD-L1) expression was measured in PTC tissues and IL-10 pretreated cells of K1 and TPC-1.

Results: Increased level of IL-10 and MHC class I were observed in PTC with concomitant HT. IL-10 stimulation increased MHC class I expression of PTC cells in vitro. Coculture of PBLs with IL-10 pretreated PTC cells enhanced T cell activation (%CD25+ of CD3+T cells) and increased IL-2 production along with decreased IFN-γ secretion and PD-1 expression. Reduced PD-L1 expression was seen in PTC+HT tissue samples and IL-10 stimulated PTC cell lines.

Conclusion: Elevated IL-10 expression in PTC with concomitant HT restores MHC class I expression and interferes tumor immunity. IL-10 may facility cancer immunotherapy in MHC class I reduced malignancies.

Keywords

Recommended Conferences

Euro-Global Summit on Probiotics

Zurich, Switzerland

World Congress on Histopathology & Cytopathology

Kyoto, Japan

18th Asia Pacific Pathology Congress

Tokyo, Japan
Share This Page
Top