alexa Immunohistochemical Expression of Androgen and Estrogen Receptors | OMICS International| Abstract
ISSN: 2476-2024

Diagnostic Pathology: Open Access
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Case Report   
  • Diagn Pathol Open 3:147,
  • DOI: 10.4172/2476-2024.100014

Immunohistochemical Expression of Androgen and Estrogen Receptors

Manwar Al-Nandy and AlSaiyed Alshenay*
Department of Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt
*Corresponding Author : AlSaiyed Alshenay, Department of Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt, Tel: 0020403296201, 00201201892237

Received Date: Oct 12, 2018 / Accepted Date: Oct 30, 2018 / Published Date: Nov 09, 2018

Abstract

Urothelial carcinoma is the most common malignancy affecting the urinary tract. It is at least three times more common in males than females suggesting the role of sex hormones in initiation and progression of bladder cancer. The purpose of this study is to detect the immunohistochemical expression of androgen receptors (AR) and estrogen receptor-β (ERβ) in urothelial carcinoma and correlate their expression with the known prognostic parameters of urothelial carcinoma. Seventy cases of urothelial carcinoma from radical cystectomy (15 specimens) and transurethral resection of the tumor (TURT) (55 specimens) were collected retrospectively. They were stained for AR and ERβ. The relationship between their expression and the available clinicopathological features were evaluated. AR/ERβ was positive in 62.9%/52.9% respectively of the studied cases. Significantly lower expression of AR/higher expression of ERβ were found in high-grade tumors (52.4%/66.7% respectively) and with muscle-invasive tumors (48.4%/71% respectively). AR and ERβ expression were significantly correlated with the tumor grade and degree of invasion suggesting the suitability of AR and ERβ as prognostic markers of urothelial carcinoma. High AR expression was associated with favorable prognosis of urothelial carcinoma in contrast to high ERβ expression which was associated with bad prognosis of urothelial carcinoma.

Keywords: Androgen; Estrogen; Receptor; Bladder cancer; Urothelial; Immunohistochemistry; Prognosis

Citation: Al-Nandy M, Alshenay A (2018) Immunohistochemical Expression of Androgen and Estrogen Receptors. Diagn Pathol Open 3: 147. Doi: 10.4172/2476-2024.100014

Copyright: © 2018 Al-Nandy M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Recommended Conferences

Euro-Global Summit on Probiotics

Zurich, Switzerland

World Congress on Histopathology & Cytopathology

Kyoto, Japan

18th Asia Pacific Pathology Congress

Tokyo, Japan
Article Usage
  • Total views: 1638
  • [From(publication date): 0-0 - Feb 23, 2020]
  • Breakdown by view type
  • HTML page views: 1557
  • PDF downloads: 81
Top