Impairment of the Posterior Part of the Mirror Neurons System in Alzheimer's Disease: Evidence from EEG Biomarkers*Corresponding Author: Moretti DV, IRCCS S. Giovanni di Dio Fatebenefratelli, via Pilastroni, 4 25125, Brescia, Italy, Tel: +393924737701, Email: [email protected]
Received Date: Mar 10, 2014 / Accepted Date: Apr 30, 2014 / Published Date: May 30, 2014
Citation: Moretti DV, PaternicÃ² D, Binetti G, Zanetti O, Frisoni GB (2014) Impairment of the Posterior Part of the Mirror Neurons System in Alzheimer’s Disease: Evidence from EEG Biomarkers. J Alzheimers Dis Parkinsonism 4:153.DOI: 10.4172/2161-0460.1000153
Copyright: © 2014 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Mirror neurons have been localized in several locations, including the inferior parietal lobule (IPL). Increase of EEG alpha3/alpha2 frequency ratio has been detected in mild cognitive impairment (MCI) subjects who will convert in Alzheimer’s disease (AD). We investigated of the association of alpha3/alpha2 frequency ratio with cortical thickness in IPL in MCI. 74 adult subjects with MCI underwent EEG recording and high resolution MRI. Alpha3/alpha2 power ratio as well as cortical thickness was computed for each subject. Three MCI groups were obtained according to increasing tertile values of alpha3/alpha2 ratio. Difference of cortical thickness among the groups was estimated. High a3/2 group had wider cortical thinning than other groups, mapped on the IPL, Supramarginal and Precuneus bilaterally. High EEG alpha3/alpha2 frequency power ratio was associated with atrophy of IPL areas in MCI subjects. A link between AD and disrupture of mirror neurons system could be hypothesized.