Importance of Bacteria as Trigger in Inflammatory Bowel Disease | OMICS International | Abstract
ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Importance of Bacteria as Trigger in Inflammatory Bowel Disease

Jérémy Denizot1,2, Nicolas Dreux1,2, Arlette Darfeuille-Michaud1,2,3 and Nicolas Barnich1,2,3*
1Clermont Université, M2iSH, Microbe intestin inflammation et Susceptibilité de l’Hôte, UMR 1071 Inserm/Université d’Auvergne, France
2Unité Sous Contrat Institut National de la Recherche Agronomique 2018, Clermont-Ferrand F-63001, France
3Institut Universitaire de Technologie, Génie Biologique, Aubière F-63172, France
Corresponding Author : Nicolas Barnich
M2iSH, Inserm/Université d’Auvergne UMR 1071
CBRV, 28 place Henri Dunant
63001 Clermont-Ferrand, France
Tel: (33)4-73-17-83-76
Fax: (33)4-73-17-83-71
E-mail: [email protected]
Received January 06, 2012; Accepted February 03, 2012; Published February 05, 2012
Citation: Denizot J, Dreux N, Michaud AD, Barnich N (2012) Importance of Bacteria as Trigger in Inflammatory Bowel Disease. J Gastroint Dig Syst S8:003. doi:10.4172/2161-069X.S8-003
Copyright: © 2012 Denizot J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Inflammatory bowel diseases (IBD) provide a complex model of host-microbe interactions underpinning disease pathogenesis. Although there is no widespread agreement on the aetiology of IBD, there is evidence that microorganisms lead to the often severe inflammatory response characteristic of the disease. IBD is thought to result from an inappropriate and continuing inflammatory response to pathobionts microbes in a genetically susceptible host. In this review, we discuss the complex microbial ecosystem of the mammalian gut, the underlying genetic factors that predispose to IBD, and how these gene variants may alter host-microbe interactions and propagate inflammation. Incentive should be given to research that will promote a better understanding of host-microbial interactions in the intestine and lay the foundations for new therapeutic approaches to both treat and prevent onset and relapse of intestinal inflammation in genetically susceptible hosts.