Abstract

Utilizing the Surveillance, Epidemiology, and End Results (SEER) database to examine the homogeneous and heterogeneous risk factors for occurrence and prognosis in lung cancer patients with bone metastasis (BM). Between 2010 and 2015, the SEER database analyzed the medical records of lung cancer patients with or without bone metastasis. A multivariate Cox regression was used to determine the prognostic effects of each variable on survival, and a multivariate logistic regression was used to identify risk factors. The SEER database contained 34,585 eligible patients who were included in the analysis. Male gender and liver metastasis were positively associated with a risk of bone metastasis in lung cancer patients, as was the prognosis of the disease. Adenocarcinoma, metastasis to the brain, a younger age, a lower grade of tumor differentiation, a higher N stage (N3), and a risk of BM were all positively correlated with an unfavorable prognosis. For the prognosis of bone metastasis, age, race, marital status, tumor size, and pathologic type were independent risk factors. A rate of 25.9% of lung cancer patients experience bone metastasis-related morbidity. This study's estimates of the homogeneous and heterogeneous risk factors for lung cancer patients' incidence and prognosis of bone metastasis may serve as clinical guidelines for doctors.