alexa Incretin-Based Therapies and Cancer Risk: A Review of Recent Literature Safety Data

Journal of Clinical Diabetes & Practice
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Incretin-Based Therapies and Cancer Risk: A Review of Recent Literature Safety Data

Cristina Scavone*, Liberata Sportiello, Concetta Rafaniello, Sonia Fiorentino, Daniela Cimmaruta, Francesco Rossi and Annalisa Capuano

Department of Experimental Medicine, Section of Pharmacology "L. Donatelli", School of Medicine, Second University of Naples

Corresponding Author:
Cristina Scavone
Seconda Universita degli
Studi di Napoli, Napoli, Italy
Tel: +00390815665805
Fax: +00390815667652
E-mail: [email protected]

Received Date: September 28, 2015 Accepted Date: November 10, 2015 Published Date: November 17, 2015

Citation: Cristina S, Liberata S, Concetta R, Sonia F, Daniela C, et al. (2015) Incretin-Based Therapies and Cancer Risk: A Review of Recent Literature Safety Data. J Clin Diabetes Pract 1:102. doi:10.4172/jcdp.1000102

Copyright: © 2015 Scavone C et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Type 2 diabetes mellitus represents almost 90–95% of all diabetes. In 2006 and in 2007, the pharmacological treatment of type 2 diabetes mellitus changed due to the introduction on the European market of the first GLP-1 receptor agonist, exenatide, and the first inhibitor of DPP-4, sitagliptin. These drugs act throughout the potentiation of incretin receptor signalling. Today, other 4 GLP-1 receptor agonists and DPP-4 inhibitors have obtained marketing approval. However as far as the safety of these drugs is concerned, some issues were recently raised regarding an increase in the risk of cancer. Therefore, in order to define the correlation between incretin-based therapies and the risk of cancer, a literature search was performed. Data was taken from recent pre-clinical and clinical studies in which tolerability of GLP-1 receptor agonists and DPP-4 inhibitors and was evaluated. In total, data obtained from 38 preclinical and clinical studies was analysed. It was evident from these studies that the risk of cancer associated to incretin-based therapies was very low. Results demonstrated that in more than 80,000 patients treated with these drugs, little over 60 cases of cancer were diagnosed. Moreover, results from EXAMINE and SAVOR-TIMI53 trials showed that the number of malignancies in patients treated with inhibitors of DPP-4 inhibitors was similar to number of cancer events occurring in patients in placebo groups. Data from pre-clinical studies also revealed encouraging results. Clearly, it is not a simple task to define the correlation between these drugs and the cancer risk especially as patients with type 2 diabetes already have a risk factor for cancer. According to the European Medicine Agency and Food and Drug Administration, it is important to continue monitoring the safety of patients treated with incretin-based therapies.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version