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Induction Therapy with S-1 for Spindle Cell Carcinoma of the External Auditory Canal | OMICS International| Abstract
ISSN: 2161-119X

Otolaryngology: Open Access
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  • Case Report   
  • Otolaryngology 2013, Vol 3(4): 149
  • DOI: 10.4172/2161-119X.1000149

Induction Therapy with S-1 for Spindle Cell Carcinoma of the External Auditory Canal

Toshiaki Yamanaka1*, Naoki Shimizu1, Yasunori Enomoto2 and Hiroshi Hosoi1
1Department of Otolaryngology-Head and Neck Surgery, Nara Medical University School of Medicine, , Japan
2Department of Diagnostic Pathology, Nara Medical University School of Medicine, , Japan
*Corresponding Author : Toshiaki Yamanaka, Department of Otolaryngology- Head and Neck Surgery, Nara Medical University School of Medicine, Kashihara, Nara, 634-8522, Japan, Tel: +81-744-29-8888, Fax: +81-744-24-6844, Email: [email protected]

Received Date: Oct 04, 2013 / Accepted Date: Oct 30, 2013 / Published Date: Nov 27, 2013


We report an unusual case of spindle cell carcinoma of the external auditory canal, which responded well to two weeks’ treatment with the oral fluoropyrimidine anticancer drug S-1 (80 mg/body/day) followed by surgical resection. After the S-1 treatment, the tumor was significantly reduced in size, and a pathological examination only detected small lesions composed of malignant cells. We then conducted a lateral temporal bone resection combined with left modified neck dissection. The patient did not demonstrate any evidence of local recurrence or distant metastasis during the 5-year follow-up period. It is suggested that S-1 played an important role in reducing the size of the tumor to allow radical resection of the tumor with a sufficient surgical margin in the present case and that induction chemotherapy with S-1 prior to surgery might be an effective treatment strategy for controlling spindle cell carcinoma of the ear.

Keywords: Spindle cell carcinoma, External auditory canal, S-1

Citation: Yamanaka T, Shimizu N, Enomoto Y, Hosoi H (2013) Induction Therapy with S-1 for Spindle Cell Carcinoma of the External Auditory Canal. Otolaryngology 3:149. Doi: 10.4172/2161-119X.1000149

Copyright: © 2013 Yamanaka T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.