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Induction Therapy with S-1 for Spindle Cell Carcinoma of the External Auditory Canal | OMICS International| Abstract
ISSN: 2161-119X

Otolaryngology: Open Access
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  • Case Report   
  • Otolaryngology 2013, Vol 3(4): 149
  • DOI: 10.4172/2161-119X.1000149

Induction Therapy with S-1 for Spindle Cell Carcinoma of the External Auditory Canal

Toshiaki Yamanaka1*, Naoki Shimizu1, Yasunori Enomoto2 and Hiroshi Hosoi1
1Department of Otolaryngology-Head and Neck Surgery, Nara Medical University School of Medicine, , Japan
2Department of Diagnostic Pathology, Nara Medical University School of Medicine, , Japan
*Corresponding Author : Toshiaki Yamanaka, Department of Otolaryngology- Head and Neck Surgery, Nara Medical University School of Medicine, Kashihara, Nara, 634-8522, Japan, Tel: +81-744-29-8888, Fax: +81-744-24-6844, Email: [email protected]

Received Date: Oct 04, 2013 / Accepted Date: Oct 30, 2013 / Published Date: Nov 27, 2013

Abstract

We report an unusual case of spindle cell carcinoma of the external auditory canal, which responded well to two weeks’ treatment with the oral fluoropyrimidine anticancer drug S-1 (80 mg/body/day) followed by surgical resection. After the S-1 treatment, the tumor was significantly reduced in size, and a pathological examination only detected small lesions composed of malignant cells. We then conducted a lateral temporal bone resection combined with left modified neck dissection. The patient did not demonstrate any evidence of local recurrence or distant metastasis during the 5-year follow-up period. It is suggested that S-1 played an important role in reducing the size of the tumor to allow radical resection of the tumor with a sufficient surgical margin in the present case and that induction chemotherapy with S-1 prior to surgery might be an effective treatment strategy for controlling spindle cell carcinoma of the ear.

Keywords: Spindle cell carcinoma, External auditory canal, S-1

Citation: Yamanaka T, Shimizu N, Enomoto Y, Hosoi H (2013) Induction Therapy with S-1 for Spindle Cell Carcinoma of the External Auditory Canal. Otolaryngology 3:149. Doi: 10.4172/2161-119X.1000149

Copyright: © 2013 Yamanaka T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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