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Hindi Review Article
Inflammatory Bowel Disease Associated Colorectal Neoplasia
| Michelle Vu1, Jyh-Yau Chang2, Jeremy Chen2 and David Q. Shih2* | |
| 1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA | |
| 2Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA | |
| Corresponding Author : | David Q. Shih, MD, PhD Cedars-Sinai Inflammatory Bowel and Immunobiology Research Institute 8700 Beverly Blvd, Suite 4066 Los Angeles, CA 90048, USA Tel: 310-423-7722 Fax: 310-423-0224 E-mail: david.shih@csmc.edu |
| Received October 31, 2011; Accepted January 21, 2012; Published January 23, 2012 | |
| Citation: Vu M, Chang JY, Chen J, Shih DQ (2012) Inflammatory Bowel Disease Associated Colorectal Neoplasia. J Gastroint Dig Syst S8:002. doi:10.4172/2161-069X.S8-002 | |
| Copyright: © 2012 Vila JJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
Abstract
Patients with ulcerative colitis (UC) or Crohn’s colitis have a greater risk for developing colorectal cancer (CRC). Many studies have described the evolving epidemiology and risk factors for CRC in patients with inflammatory bowel disease (IBD). Recent evidence indicates that the incidence has been decreasing with the advancement of medical and surgical therapies, and surveillance has emerged as the foundation of prevention. Chemoprophylaxis is another area of research; however, given the limited efficacy of these agents, they are only being used in conjunction with endoscopic surveillance. Our ability to formulate effective strategies for the prevention of this dreaded complication expands as more is discovered of the molecular events underlying IBD carcinogenesis. Management strategies are constantly updated as new evidence and endoscopic techniques emerge. In this paper, we review the literature regarding epidemiology, pathogenesis, risk factors and chemoprophylaxis as well as the latest consensus guidelines for management of dysplasia and neoplasia in IBD patients.
