alexa Inflammatory Bowel Disease Associated Colorectal Neoplasia | OMICS International
ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
Open Access

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Review Article

Inflammatory Bowel Disease Associated Colorectal Neoplasia

Michelle Vu1, Jyh-Yau Chang2, Jeremy Chen2 and David Q. Shih2*
1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA
2Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
Corresponding Author : David Q. Shih, MD, PhD
Cedars-Sinai Inflammatory Bowel and
Immunobiology Research Institute
8700 Beverly Blvd, Suite 4066
Los Angeles, CA 90048, USA
Tel: 310-423-7722
Fax: 310-423-0224
E-mail: [email protected]
Received October 31, 2011; Accepted January 21, 2012; Published January 23, 2012
Citation: Vu M, Chang JY, Chen J, Shih DQ (2012) Inflammatory Bowel Disease Associated Colorectal Neoplasia. J Gastroint Dig Syst S8:002. doi:10.4172/2161-069X.S8-002
Copyright: © 2012 Vila JJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Patients with ulcerative colitis (UC) or Crohn’s colitis have a greater risk for developing colorectal cancer (CRC). Many studies have described the evolving epidemiology and risk factors for CRC in patients with inflammatory bowel disease (IBD). Recent evidence indicates that the incidence has been decreasing with the advancement of medical and surgical therapies, and surveillance has emerged as the foundation of prevention. Chemoprophylaxis is another area of research; however, given the limited efficacy of these agents, they are only being used in conjunction with endoscopic surveillance. Our ability to formulate effective strategies for the prevention of this dreaded complication expands as more is discovered of the molecular events underlying IBD carcinogenesis. Management strategies are constantly updated as new evidence and endoscopic techniques emerge. In this paper, we review the literature regarding epidemiology, pathogenesis, risk factors and chemoprophylaxis as well as the latest consensus guidelines for management of dysplasia and neoplasia in IBD patients.

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