Inflammatory Cytokines in a Sample of Alzheimer's Patients from Rio De Janeiro State
*Corresponding Author: Dr. Luiz Felipe Da Silva Figueiredo, Department of Brazilian Music Conservatory, University in Rio de Janeiro, Rio de JaneiroWarning: Undefined variable $university_str in /efsdata/omicsonline.org/httpdocs/includes/articles_utility.php on line 338
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, Brazil, Email: gabizanetti@hotmail.com
Received Date: Oct 21, 2022 / Published Date: Nov 21, 2022
Citation: Figueiredo LFDS, Almeida C, Rodrigues LS, Dutra PML, Laks J (2022) Inflammatory Cytokines in a Sample of Alzheimer's Patients from Rio De Janeiro State. J Alzheimers Dis Parkinsonism 12:556.DOI: 10.4172/2161-0460.1000556
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Copyright: © 2022 Figueiredo LFDS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
We carried out an evaluation of a sample of 45 elderly into 2 groups GA(21)=75.9+7.4 years and GC(24)=75.3+7.5 years. We evaluated CDR, MMSE, and CST, Lawton and Brody Scale and one sample of 5 ml of blood for analysis of biomarkers. The data were compared between groups. The results showed higher levels for IL-12, IL-10 and IL-1β for Alzheimer’s disease. IL-10 was correlated with age, CDR and functional capacity and negative correlated with MMSE. The age was correlated with TNF-α, IL-10, IL-4. The CST was correlated with IL-4. We conclude that Alzheimer’s disease changes de immune system with higher inflammatory cytokine and correlated with functional and cognitive capacity impacting the elderly health.