ISSN: 2161-1165

Epidemiology: Open Access
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  • Research Article   
  • Epidemiology (Sunnyvale) 2018, Vol 8(4): 359
  • DOI: 10.4172/2161-1165.1000359

Interaction between Risk Factors and Gastric Cancer: A Population-Based Case-Control Study in a High Risk Chinese Area

Yulan Lin1#, Meihua Jiang2#, Chuancheng Wu3,4, Wei Yan5, Saixiong Guo6, Su Lin7, Nele Brusselaers8 and Baoying Liu3,4*
1Department of Health Law and Health Police, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China
2Department of Hygiene, Fujian Center for Disease Control and Prevention, Fuzhou, Fujian, China
3Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China
4Fujian Provincial Key Laboratory of Environment Factors and Cancer, Fujian Medical University, Fuzhou, China
5Fujian Xianyou Health and Family Planning Authority, Putian, China
6Fujian Xianyou County Hospital, Putian, China
7Liver Research Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China
8Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, Stockholm, Sweden
#Contributed equally to this work
*Corresponding Author : Baoying Liu, Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China, Tel: +008615159614573, Email: liuby5@126.com

Received Date: Oct 20, 2018 / Accepted Date: Nov 02, 2018 / Published Date: Nov 05, 2018

Abstract

Introduction: An extremely high prevalence of gastric cancer (GC) was observed in Xianyou County, the Southeastern of China, yet it remains unclear how interaction of environmental factors affects the GC risk in this area.
Methods: A population-based case-control study was conducted during March 2013 and January 2017 in Xianyou County. All newly diagnosed patients with GC were compared with healthy controls matched (1:1) by sex, age (± 3 years) and place of residence.
Results: A total of 622 cases of GC and 622 matched healthy controls were included. Participants who consumed pickled vegetables and had a preference for hard solid food had the highest risk of GC (adjusted OR=12.42, 95% CI: 7.56-20.41) compared to individuals who did not have such food patterns. Increased GC risk was also observed among those who consumed pickled vegetables but not drink tea (adjusted OR=6.88, 95% CI: 3.74-12.66), compared to those drinking tea but did not consume pickled vegetables. Furthermore, participants who did not consume tea but were exposed to pesticides during farm work also had 2.50 times (95% CI: 1.30-4.80) higher risk of GC risk compared to those had tea consumption but were not exposed to pesticides. No statistically significant interactions were observed for pesticide exposure, smoking, beef or pork consumption, fruit consumption, chronic atrophic gastritis and family history of any cancer in relation to GC.
Conclusion: Strong synergistic effects in raising the risk of GC were seen between pickled vegetables consumption and hard solid food preference, as well as between pickled vegetables consumption and not drinking tea.

 

Keywords: Combined effect; Oncology; Stomach cancer

Citation: Lin Y, Jiang M, Wu C, Yan W, Guo S, et al. (2018) Interaction between Risk Factors and Gastric Cancer: A Population-Based Case- Control Study in a High Risk Chinese Area. Epidemiology (Sunnyvale) 8: 359 Doi: 10.4172/2161-1165.1000359

Copyright: © 2018 Lin Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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