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Interferon-Gamma +874 (T/A) Polymorphism and Susceptibility to Aplastic Anemia: A Systematic Review and Meta-Analysis | OMICS International| Abstract
ISSN: 2471-9919

Evidence based Medicine and Practice
Open Access

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  • Research Article   
  • Evid Based Med Pract,
  • DOI: 10.4172/2471-9919.1000112

Interferon-Gamma +874 (T/A) Polymorphism and Susceptibility to Aplastic Anemia: A Systematic Review and Meta-Analysis

Bahman Razi1, Shahab Alizadeh2*, Danyal Imani3, Ramazan Rezaei3 and Azadeh Omidkhoda1
1Department of Hematology and Blood Banking, School of Allied Medical Sciences, Tehran University of Medical Sciences (TUMS), , Tehran, Iran
2Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), , Tehran, Iran
3Department of Immunology, School of Medicine, Tehran University of Medical Sciences (TUMS), , Tehran, Iran
*Corresponding Author : Shahab Alizadeh, Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran, Tel: +98-9197604090, Fax: +98-21-889 559 79, Email: sh_alizadeh@razi.tums.ac.ir

Received Date: Apr 07, 2017 / Accepted Date: May 23, 2017 / Published Date: Jun 09, 2017

Abstract

Background: Many studies have assessed the relation between IFN-γ +874(T/A) polymorphism and risk of aplastic anemia. However, the results of these studies were inconclusive. In the current study, we performed a metaanalysis to evaluate the association between IFN-γ +874(T/A) polymorphism and susceptibility to aplastic anemia.
Methods: All publications were searched precisely to find eligible articles on IFN-γ polymorphism +874(T/A) and aplastic anemia. Odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated to evaluate the strength of association in the dominant model, recessive model, allelic model, homozygotes contrast, and heterozygotes contrast.
Results: A total of 4 case-control studies, including 210 cases and 537 healthy controls were elegble for this metta-analysis. Combined analysis of these studies showed no significant association between the IFN-γ polymorphism +874(T/A) and aplastic anemia risk in the overall population (dominant model: OR=1.52, 95% CI=0.57-2.46; recessive model: OR=1.27, 95% CI=0.47-2.08; allelic model: OR=0.98, 95% CI=0.63-1.34; TT vs. AA: OR=3.68, 95% CI=0.21-7.15, and AT vs. AA: OR=1.20, 95% CI=0.43-1.97). No heterogeneity or publication bias was observed in this study. Conclusion: This meta-analysis showed that the IFN-γ +874(T/A) polymorphism was not associated with the risk of aplastic anemia.To confirm our results, further studies are needed.

Keywords: IFN- γ, Polymorphism, Aplastic anemia, Meta-analysis

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Citation: Razi B, Alizadeh S, Imani D, Rezaei R, Omidkhoda A (2017) Interferon- Gamma +874 (T/A) Polymorphism and Susceptibility to Aplastic Anemia: A Systematic Review and Meta-Analysis. Evid Based Med Pract 3: 112. Doi: 10.4172/2471-9919.1000112

Copyright: © 2017 Razi B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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