ISSN: 2471-9919

Evidence based Medicine and Practice
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Research Article   
  • Evid Based Med Pract,
  • DOI: 10.4172/2471-9919.1000112

Interferon-Gamma +874 (T/A) Polymorphism and Susceptibility to Aplastic Anemia: A Systematic Review and Meta-Analysis

Bahman Razi1, Shahab Alizadeh2*, Danyal Imani3, Ramazan Rezaei3 and Azadeh Omidkhoda1
1Department of Hematology and Blood Banking, School of Allied Medical Sciences, Tehran University of Medical Sciences (TUMS), , Tehran, Iran
2Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), , Tehran, Iran
3Department of Immunology, School of Medicine, Tehran University of Medical Sciences (TUMS), , Tehran, Iran
*Corresponding Author : Shahab Alizadeh, Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran, Tel: +98-9197604090, Fax: +98-21-889 559 79, Email: sh_alizadeh@razi.tums.ac.ir

Received Date: Apr 07, 2017 / Accepted Date: May 23, 2017 / Published Date: Jun 09, 2017

Abstract

Background: Many studies have assessed the relation between IFN-γ +874(T/A) polymorphism and risk of aplastic anemia. However, the results of these studies were inconclusive. In the current study, we performed a metaanalysis to evaluate the association between IFN-γ +874(T/A) polymorphism and susceptibility to aplastic anemia.
Methods: All publications were searched precisely to find eligible articles on IFN-γ polymorphism +874(T/A) and aplastic anemia. Odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated to evaluate the strength of association in the dominant model, recessive model, allelic model, homozygotes contrast, and heterozygotes contrast.
Results: A total of 4 case-control studies, including 210 cases and 537 healthy controls were elegble for this metta-analysis. Combined analysis of these studies showed no significant association between the IFN-γ polymorphism +874(T/A) and aplastic anemia risk in the overall population (dominant model: OR=1.52, 95% CI=0.57-2.46; recessive model: OR=1.27, 95% CI=0.47-2.08; allelic model: OR=0.98, 95% CI=0.63-1.34; TT vs. AA: OR=3.68, 95% CI=0.21-7.15, and AT vs. AA: OR=1.20, 95% CI=0.43-1.97). No heterogeneity or publication bias was observed in this study. Conclusion: This meta-analysis showed that the IFN-γ +874(T/A) polymorphism was not associated with the risk of aplastic anemia.To confirm our results, further studies are needed.

Keywords: IFN- γ, Polymorphism, Aplastic anemia, Meta-analysis

Citation: Razi B, Alizadeh S, Imani D, Rezaei R, Omidkhoda A (2017) Interferon- Gamma +874 (T/A) Polymorphism and Susceptibility to Aplastic Anemia: A Systematic Review and Meta-Analysis. Evid Based Med Pract 3: 112. Doi: 10.4172/2471-9919.1000112

Copyright: © 2017 Razi B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Top