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ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
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Case Report

Intracranial Tumorous Lesion as the First Manifestation of Langerhans Cell Histiocytosis: A Diagnostic and Therapeutic Challenge - Case Report

Jolanta Florczak Wyspianska1*, Michał Owecki1, Małgorzata Rzymkowska2, Halina Batura Gabryel2 and Wojciech Kozubski1

1Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland

2Department of Pulmonology, Allergology, and Pulmonological Oncology, Poznan University of Medical Sciences, Poznan, Poland

Corresponding Author:
Jolanta Florczak Wyspianska
Poznan University of Medical Sciences
Department of Neurology, Przybyszewskiego
Poznan, Poland
Tel: 0048601878101
E-mail: [email protected]

Received date: December 05, 2016; Accepted date: January 09, 2017; Published date: January 16, 2017

Citation: Wyspianska JF, Owecki M, Rzymkowska M, Gabryel HB, Kozubski W (2017) Intracranial Tumorous Lesion as the First Manifestation of Langerhans Cell Histiocytosis: A Diagnostic and Therapeutic Challenge - Case Report. J Alzheimers Dis Parkinsonism 7:298. doi:10.4172/2161-0460.1000298

Copyright: © 2017 Wyspianska JF. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Langerhans cell histiocytosis (LHC) is a rare proliferative disease of unknown etiology characterized by bone marrow-derived histiocyte-like cell proliferation. The disease is confirmed by electron microscopy or immunohistochemical reactivity of histiocytes to the CD1a receptor, langerin (CD207) and/or S100 protein. The clinical spectrum ranges from an acute disseminated disease to solitary or few chronic lesions of bone or other organs. Central nervous system invasion in LCH patients has rarely been reported, especially in the adult population. We report a case of an intracranial tumorous lesion as the first manifestation of LCH in a 23 year old Caucasian man. The patient presented a 2 year history of cognitive decline and a 7 year history of diabetes insipidus, diabetes mellitus, hypothyroidism and obesity. The histopathological findings of a lesion located in the hypothalamic region confirmed the diagnosis of LCH.

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