Isoniazid with Multiple Mode of Action on Various Mycobacterial Enzymes Resulting in Drug ResistanceLingaraja Jena, Tapaswini Nayak, Shraddha Deshmukh, Gauri Wankhade, Pranita Waghmare and Bhaskar C Harinath*
Bioinformatics Centre, Biochemistry & JBTDRC, MGIMS, Sevagram, Maharashtra, India
- *Corresponding Author:
- Harinath BC
JB Tropical Disease Research Centre, Mahatma Gandhi Institute of Medical Sciences
Sevagram, 442 102 (Wardha) Maharashtra, India
E-mail: [email protected]
Received date: September 11, 2016; Accepted date: October 17, 2016; Published date: October 20, 2016
Citation: Jena L, Nayak T, Deshmukh S, Wankhade G, Waghmare P, et al. (2016) Isoniazid with Multiple Mode of Action on Various Mycobacterial Enzymes Resulting in Drug Resistance. J Infect Dis Ther 4:297. doi:10.4172/2332-0877.1000297
Copyright: © 2016 Jena L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Isoniazid (INH), is one of the drugs shown to be effective and has been extensively used in TB control. Interestingly tuberculosis showed predominant drug resistance to isoniazid and thus lead to multi drug therapy in TB treatment. However, isoniazid is still advocated in latent TB and use as prophylactic in HIV infection and in children for prevention of TB. It is of interest that different studies revealing interaction of isoniazid with around 117 enzymes of mycobacteria influencing metabolic pathways by number of ways in addition to inhibiting mycolic acid synthesis and thus affecting growth of mycobacteria. The purpose of this review is to present the various mechanisms of action of isoniazid at different enzymes of MTB causing drug resistance.