alexa Laryngopharyngeal Reflux and#8211; A Randomized Clinical Controlled Trial | OMICS International| Abstract
ISSN: 2161-119X

Otolaryngology: Open Access
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Research Article   
  • Otolaryngology 2011, Vol 1(1)
  • DOI: 10.4172/2161-119X.S1-004

Laryngopharyngeal Reflux – A Randomized Clinical Controlled Trial

Mette Pedersen* and Martin Egg Cand Stat
The Medical Centre, Oestergade 18, Laryngeal Unit. Dk 1100 Copenhagen, , Denmark
*Corresponding Author : Mette Pedersen MD, The Medical Centre, Oestergade 18, Laryngeal Unit. Dk 1100 Copenhagen, Denmark, Tel: 0045 33137700, Fax: 0045 33137705, Email: [email protected]

Received Date: Mar 15, 2012 / Accepted Date: Apr 15, 2012 / Published Date: Apr 20, 2012

Abstract

Study background: The objective of this study was to make a Randomized Controlled Trial (RCT) of laryngopharyngeal reflux treatment based on a sufficient number of patients (referring to our Cochrane review 2009).

Material and methods: In order to detect differences prospectively of treatment effect in a randomized controlled trial, the following treatments of Laryngopharyngeal Reflux (LPR) were compared: lifestyle advice, lifestyle advice combined with proton pump inhibitor, and life style advice combined with proton pump inhibitor and alginate. Subjective complaints of LPR were stored and the objective evaluation of interarytenoids oedema of the larynx was evaluated visually on high speed films, with minimum of 2000 frames per second, a supplement of routine acoustical measures were made.

Results: A total of 237 patients were randomized based on the planned statistical power calculation of 90% to detect a difference of 20%, under the assumption that the true difference was 5% and that the standard deviation was 25%. The differences between the three groups were found not to be statistically significant, but there was a general positive effect of treatment.

Conclusion: Lifestyle guidance, lifestyle guidance added with esomeprazole and lifestyle guidance added with esomeprazole and alginate were all effective in this RCT for treatment effect of laryngopharyngeal reflux based on subjective complaints and documented with high speed films with minimum 2000 frames per second.

Keywords: Alginate, Esomeprazole, High speed films, Laryngopharyngeal reflux

Citation: Pedersen M, cand Stat ME (2012) Laryngopharyngeal Reflux ? A Randomized Clinical Controlled Trial. Otolaryngol S1:004. Doi: 10.4172/2161-119X.S1-004

Copyright: © 2012 Pedersen M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Recommended Conferences
Article Usage
  • Total views: 13163
  • [From(publication date): 6-2011 - Oct 25, 2020]
  • Breakdown by view type
  • HTML page views: 9321
  • PDF downloads: 3842
Top