alexa
Reach Us +1(631)596-0675
Management of Patients with Ulcerative Colitis after Proctocolectomy:Pouchitis is a Real Danger | OMICS International | Abstract
ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Management of Patients with Ulcerative Colitis after Proctocolectomy:Pouchitis is a Real Danger

Tamás Molnár*, Klaudia Farkas, Ferenc Nagy, Zoltán Szepes and Tibor Wittmann

First Department of Medicine, University of Szeged, Szeged, Hungary

*Corresponding Author:
Tamás Molnár
First Department of Medicine
University of Szeged, H-6720
Korányi fasor 8, Szeged, Hungary
Tel: +36-62-545186
Fax: +36-62-545185
E-mail: [email protected]

Received date: September 12, 2011; Accepted date: November 14, 2011; Published date: November 16, 2011

Citation: Molnár T, Farkas K, Nagy F, Szepes Z, Wittmann T (2011) Management of Patients with Ulcerative Colitis after Proctocolectomy: Pouchitis is a Real Danger. J Gastrointest Dig Syst 1:102. doi:10.4172/2161-069X.1000102

Copyright: © 2011 Molnár T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Pouchitis develops in about 50% of the patients with ulcerative colitis (UC) undergoing colectomy.

Aim: The aim of this study was to evaluate the frequency of pouchitis, to determine risk factors and to assess the efficacy of infliximab in refractory pouchitis.

Patients and Methods: 76% of the 46 UC patients requiring colectomy underwent ileal pouch-anal anastomosis (IPAA) procedure. Demographic, clinical and therapeutic parameters were compared between patients who did and did not develop pouchitis and between those with pouchitis responding or being refractory to the conservative therapy.

Results: 40% of the patients developed pouchitis. Six patients received infliximab therapy. Extraintestinal manifestation and non smoking was characteristic for refractory pouchitis.

Discussion: Pouchitis developed in 40% of our patients undergoing IPAA. The development of pouchitis seems to be predisposed by frequent preoperative hospitalization. The earlier onset of pouchitis seems to be a prognostic factor for the unsuccessful conservative treatment and the need for biological therapy.

Keywords

Recommended Conferences
Share This Page
Top