Matching on Race and Ethnicity in Case-Control Studies as a Means of Control for Population Stratification
Received Date: Aug 24, 2011 / Accepted Date: Sep 20, 2011 / Published Date: Sep 29, 2011
Some investigators argue that controlling for self-reported race or ethnicity, either in statistical analysis or in study design, is sufficient to mitigate unwanted influence from population stratification. In this report, we evaluated the effectiveness of a study design involving matching on self-reported ethnicity and race in minimizing bias due to population stratification within an ethnically admixed population in California. We estimated individual genetic ancestry using structured association methods and a panel of ancestry informative markers, and observed no statistically significant difference in distribution of genetic ancestry between cases and controls (P=0.46). Stratification by Hispanic ethnicity showed similar results. We evaluated potential confounding by genetic ancestry after adjustment for race and ethnicity for 1260 candidate gene SNPs, and found no major impact (>10%) on risk estimates. In conclusion, we found no evidence of confounding of genetic risk estimates by population substructure using this matched design. Our study provides strong evidence supporting the race- and ethnicity-matched case-control study design as an effective approach to minimize systematic bias due to differences in genetic ancestry between cases and controls.
Keywords: Population stratification; Genetic susceptibility; Case-control; Matching.
Citation: Chokkalingam AP, Aldrich MC, Bartley K, Hsu LI, Metayer C, et al. (2011) Matching on Race and Ethnicity in Case-Control Studies as a Means of Control for Population Stratification. Epidemiol 1:101. Doi: 10.4172/2161-1165.1000101
Copyright: © 2011 Chokkalingam AP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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