alexa Medroxyprogesterone Acetate and Progesterone Measurement in Human Serum: Assessments of Contraceptive Efficacy | OMICS International | Abstract
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Medroxyprogesterone Acetate and Progesterone Measurement in Human Serum: Assessments of Contraceptive Efficacy

Molly S Augustine, Andrea E Bonny and Lynette K Rogers*

Centers for Perinatal and Clinical and Translational Research, The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, USA

*Corresponding Author:
Lynette K Rogers, Ph.D.
Center for Perinatal Research
The Research Institute at Nationwide Children’s Hospital
575 Children’s Cross Road, Columbus, Ohio
Department of Pediatrics, The Ohio State University, USA
Tel: 614-355-6715
Fax: 614-355-6675
E-mail: [email protected]

Received date: December 03, 2013; Accepted date: January 10, 2014; Published date: January 13, 2014

Citation: Augustine MS, Bonny AE, Rogers LK (2014) Medroxyprogesterone Acetate and Progesterone Measurement in Human Serum: Assessments of Contraceptive Efficacy. J Anal Bioanal Tech S5:005. doi: 10.4172/2155-9872.S5-005

Copyright: © 2014 Augustine MS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Medroxyprogesterone (MPA) is widely used as a contraceptive or for hormone replacement therapy after menopause. The use of MPA, specifically in adolescent girls, is linked to excess weight gain and decreases in bone mineral density. Metabolism and clearance of MPA is highly variable making this agent a candidate for individualized dosing strategies which could possibly decrease unwanted side effects. MPA has been measured in animal tissues and fluids for many years as a contaminant resulting from the use of growth hormones in food animals.

MPA has been measured by radioimmunoassay, gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS/MS). LC-MS/MS techniques have proven to be both more specific than radioimmunoassay and required much simpler sample preparation techniques than GC-MS. Here we describe an LC-MS/MS method specifically designed for monitoring MPA and progesterone levels in human serum. The technique in this report involves minimal sample preparation and yields results with precision and accuracy suitable for clinical use

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version