ISSN: 2476-2024

Diagnostic Pathology: Open Access
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  • Case Report   
  • Diagn Pathol Open 2016, Vol 1(2): 114
  • DOI: 10.4172/2476-2024.1000114

Metastatic Monophasic Synovial Sarcoma: A challenging Diagnosis on Fine Needle Aspiration with Broad Differential Diagnosis

Ghassan Tranesh1, Sarah Kerr2 and Aziza Nassar1*
1Department of Pathology, , Mayo Clinic, Jacksonville, FL, USA
2Department of Pathology, , Mayo Clinic, Rochester, MN, USA
*Corresponding Author : Aziza Nassar, Department of Pathology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, Fl, 32224, USA, Tel: 904-956-3318, Fax: 904-956-3336, Email: Nassar.aziza@mayo.edu

Received Date: Apr 26, 2016 / Accepted Date: May 27, 2016 / Published Date: May 31, 2016

Abstract

Synovial sarcomas (SS) are rare soft tissue sarcomas that usually arise near large extremity joints. SS may pose difficult diagnostic challenges on cytology when encountered as a monophasic variant. We report a 27-year-old woman diagnosed with metastatic monophasic synovial sarcoma by a CT-scan guided fine needle aspiration (FNA) biopsy of a left lower lung lobe nodule. We reviewed the literature on the epidemiologic, cytohistological spectrum, immunophenotypic, and the molecular findings and discussed the differential diagnosis for this rare entity.

Keywords: FNA; Monophasic; Synovial sarcoma; Metastatic; SS18- SSX1 fusion

Citation: Tranesh G, Kerr S, Nassar A (2016) Metastatic Monophasic Synovial Sarcoma: A challenging Diagnosis on Fine Needle Aspiration with Broad Differential Diagnosis. Diagn Pathol Open 1:114. Doi: 10.4172/2476-2024.1000114

Copyright: ©2016 Tranesh G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Review summary

  1. Vasistha Kaur
    Posted on Aug 24 2016 at 11:21 am
    The case report discussed on metastatic monophasic synovial sarcoma. The diagnosis was made based on the results related to cytology, immunohistochemistry and molecular examination on cells recovered from fine needle aspiration of the lung nodule. Though the rarity and the diagnostic difficulty of synovial sarcoma are well reported, the current manuscript illustrated interesting case involving a young woman with recurrent relapse of 'spindle cell sarcoma'. In total, the patient was presented three times, first and second presentations for a lump in her left thigh whilst a lung nodule detected via routine MRI, was the current presentation.
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