alexa Micro-MRI-based Detection of Tissue Damage in the Liver, Pancreas, and Kidney during the Early Phases of an LPS and D-Galactosamine-Induced Hepatic Injury Model in Mice | Abstract
ISSN: 2476-2024

Diagnostic Pathology: Open Access
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Micro-MRI-based Detection of Tissue Damage in the Liver, Pancreas, and Kidney during the Early Phases of an LPS and D-Galactosamine-Induced Hepatic Injury Model in Mice

Nodoka Nago1*, Misao Yoneda2, Samuel Darkwah1, Eiji Kawamoto1,3, Eun Jeong Park1 and Motomu Shimaoka1
1Department of Molecular Pathobiology and Cell Adhesion Biology, Graduate School of Medicine, Mie University, 2-174 Edobashi Tsu-City, Mie 514-8507, Japan
2Department of Clinical Nutrition, Suzuka University of Medical Science, 1001-1 Kishioka, Suzuka-City, Mie 510-0293, Japan
3Department of Disaster and Emergency Medicine, Mie University Graduate School of Medicine, 2-174 Edobashi Tsu-City, Mie 514-8507, Japan
*Corresponding Author: Nodoka Nago, M.D., Ph.D, Department of Molecular and Pathobiology and Cell Adhesion Biology, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu-city, Mie 514-8507, Japan, Tel: +81-59-232-5036, Fax: +81-59-231-5209, Email: [email protected]

Received Date: Jan 21, 2020 / Accepted Date: Feb 05, 2020 / Published Date: Feb 12, 2020

Citation: Nago N, Yoneda M, Darkwah S, Kawamoto E, Park EJ, et al. (2020) Micro-MRI-based Detection of Tissue Damage in the Liver, Pancreas, and Kidney during the Early Phases of an LPS and D-Galactosamine-Induced Hepatic Injury Model in Mice. Diagn Pathol Open 5: 161.

Copyright: © 2020 Nago N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 
To read the full article Peer-reviewed Article PDF image

Abstract

How tissue injuries progress among organs during LPS-induced fulminant hepatic failure remains to be elucidated, especially during the very acute phase of small animal models. We have addressed this problem in LPS/D-galactosamine-induced fulminant hepatitis by using sequential micro-MRI scanning. Analysis of T2-weighted MRI signal intensities detected tissue injury in the liver during the early phase (as early as the 3 h timepoint), at which point histological examination revealed only minor morphological changes in hepatic tissues. In the pancreas, increases in the T2-weighted signals were made readily apparent by the pancreatic edema formation that was determined by histological examination. Only minimal pathologies were observed in the renal cortex based on micro-MRI and histological examination. The results of this study have demonstrated the distinct temporal changes that occur in the liver and injured pancreatic acinar cells during the very acute phase of LPS-induced hepatitis.

Keywords

Recommended Conferences

Euro-Global Summit on Probiotics

Zurich, Switzerland

World Congress on Histopathology & Cytopathology

Kyoto, Japan

18th Asia Pacific Pathology Congress

Tokyo, Japan
Share This Page
Top