Molecular Docking Studies on Potent Adsorbed Receptor of Thrh Protein: A New Target for Biodegradation of Indigo Dye
- Corresponding Author:
- Prabhavathi P
PG and Research Department of Microbiology
PSG College of Arts and Science, Coimbatore
Tamil Nadu, India
E-mail: [email protected]
Received Date: May 12, 2016; Accepted Date: June 06, 2016; Published Date: June 13, 2016
Citation: Prabhavathi P, Rajendran R, Karthik Sundaram S, Dinesh Kumar S, Santhanam P, et al. (2016) Molecular Docking Studies on Potent Adsorbed Receptor of Protein: A New Target for Biodegradation of Indigo Dye. J Bioremed Biodeg 7:356. doi: 10.4172/2155-6199.1000356
Copyright: © 2016 Prabhavathi P, et al. This is an open-a ccess article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Vat dyes are aromatic compounds widely used for denim textile industries, this result in a great wastewater problem from this industry due to recalcitrant nature of these dyes. The active protein (ThrH) was purified from Pseudomonas aeruginosa by DEAE-Sepharose A-50 column chromatography and this 3D crystal structure was reported recently. The present study aimed to demonstrate the binding energy between 3D crystal structures of indigo dye and ThrH. We have calculated the gliding score as well as gliding energy based on the hydrophobic interactions between targeted sites (amino acid and dye residue) and the main think is binding energy which was observed maximum level because of the presence of magnesium ions along with catalytic molecules located at the binding sites. The dye degraded mineralized compound was predicted by mass spectrum and infrared spectroscopy.