ISSN: 2476-2024

Diagnostic Pathology: Open Access
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Case Series   
  • Diagn Pathol Open 5: 167,
  • DOI: 10.4172/2476-2024.1000167

Nail Involvement as the Only Onset Manifestation of Pemphigus Vulgaris

Jose Salvador García-Morillo1*, Francisco Javier Nieto Garcia1, Alberto Ruiz Román2 and Alejandro Ortiz Prieto3
1Rare and Autoimmune Disease Unit, Internal Medicine Service, Virgen del Rocio University Hospital, Seville, Spain
2Rheumatology Unit, Virgen del Rocio University Hospital, Seville, Spain
3Dermatology Unit, Virgen del Rocio University Hospital, Seville, Spain
*Corresponding Author : Dr. Jose Salvador García-Morillo, Rare and Autoimmune Disease Unit, Internal Medicine Service, Virgen del Rocio University Hospital, Seville, Spain, Tel: (+34)678421588, Email: salvaymar@gmail.com

Received Date: Jul 23, 2020 / Accepted Date: Aug 06, 2020 / Published Date: Aug 13, 2020

Abstract

Pemphigus vulgaris (PV) is a blistering autoimmune, chronic and uncommon disease that affects the skin, mucous membranes and skin appendages. The onset of the disease usually consists of mucosal lesions (50%-70%), skin manifestations (10%-15%), or both. Nail involvement usually develops in association with the previously mentioned manifestations, being exceptionally the only affected area at the onset of the disease.

A 52 year old patient with no important medical history was evaluated after two weeks of antibiotic treatment for painful, swollen, erythematous-violaceous, poorly delimited lesions, with subungueal haemorrhage, affecting the nails and periungueal tissue of the first and third right toes and the third left finger; the nail plate presented hyperkeratosis, yellowish discoloration and distal onycholysis. Complementary blood analysis and skin cultures did not reveal positive results. A skin biopsy showed suprabasal acantholytic dermatosis with no inflammatory components, and immunofluorescence manifested IgG intercellular deposits, with no evidence of IgA, IgM, C3 or fibrinogen deposits. Autoimmune serologic studies were positive for anti-intercellular substance antibody (1/80) and negative for anti-basal membrane and anti-nuclear antibodies. With these findings the patient was diagnosed with Pemphigus Vulgaris, being nail lesions the exclusive onset manifestation.

Keywords: Pemphigus vulgaris; Nails

Citation: Morillo JSG, Garcia FJN, Román AR, Prieto AO (2020) Nail Involvement as the Only Onset Manifestation of Pemphigus Vulgaris. Diagn Pathol Open 5: 167. Doi: 10.4172/2476-2024.1000167

Copyright: © 2020 Morillo JSG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Top