Journal of Dementia
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  • Review Article   
  • J Dement 2017, Vol 1(1): 104

Neurochemicals and Behavioural Alterations in Sleep Deprivation: A Revisit

Parameswari PR1, Chethan N2 and Saravana Babu Chidambaram2*
1SRU Centre for Indian Systems of Medicine Quality Assurance and Standardisation, Sri Ramachandra University, Chennai, India
2JSS College of Pharmacy, Jagadguru Sri Shivarathreeswara University, India
*Corresponding Author : Saravana Babu Chidambaram, Associate Professor, Department of Pharmacology, JSS College of Pharmacy, Jagadguru Sri Shivarathreeswara University, India, Tel: +91-9940434129, Email: csaravanababu@gmail.com

Received Date: Oct 19, 2017 / Accepted Date: Oct 30, 2017 / Published Date: Nov 10, 2017

Abstract

Sleep is an invigorative biological process which cannot be defined as such, but is organized through intricate interactions between various brain regions and neurochemistry. Sleep endures physical and cognitive performance, health and well-being; even mild sleep restriction degrades behavioural performance over a few days. Sleep deprivation (SD) leads to an array of disorders such as cognitive dysfunctions, attention deficits including coordination and concentration. A decrease in the cortical sensitivity to an incoming stimuli leads to defect in attention. Also sleep deprivation leads to elevated levels of excitatory neurotransmitters and abnormalities in certain other neuromodulators which ultimately has effects on neuronal and executive functions. Inspite of wide-cut literatures availability on the neurochemical deviations following sleep deprivation, this review focuses on the major neurotransmitters effects leading to behavioural alterations and the concomitant brain region activities.

Keywords: Sleep; Sleep deprivation; Neurotransmitters; Cognition; Behaviour; Neurobiology

Citation: Parameswari PR, Nagabushan C, Chidambaram BS (2017) Neurochemicals and Behavioural Alterations in Sleep Deprivation: A Revisit. J Dement 1: 104.

Copyright: ©2017 Parameswari PR, et al.. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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