ISSN: 2277-1891

International Journal of Advance Innovations, Thoughts & Ideas
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Mini Review

Neuroprotective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide

Rui Ji1, Lingbin Meng2 and Rongqiang Yang1*

1Department of Biochemistry and Molecular biology, University of Louisville, School of Medicine, Louisville, KY 40202, USA

2Department of Anatomical Sciences and Neurobiology, University of Louisville, School of Medicine, Louisville, KY 40202, USA

*Corresponding Author:
Dr. Rongqiang Yang
University of Louisville, School of Medicine
319 Abraham Flexner Way, Louisville, KY 40202, USA
E-mail: r0yang02@louisville.edu

Received date: June 15, 2014; Accepted date: June 24, 2014; Published date: June 27, 2014

Citation: Rui J, Lingbin M, Rongqiang Y (2014) Neuroprotective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide. Int J Adv Innovat Thoughts Ideas 3:156. doi:10.4172/2277-1891.1000156

Copyright: © 2014 Rui Ji, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a member of the secretin/glucagon/vasoactive intestinal peptide (VIP) super family. PACAP was first isolated from an ovine hypothalamus and named because it stimulated cAMP production in the rat pituitary cell culture. PACAP is widely expressed in the central and peripheral nervous systems. PACAP plays the roles of neurotransmitter, neuromodulator and neurotrophic factors via three Gprotein binding receptors, PAC1, VAPC1 and VPAC2. A number of recent studies have discovered the neuroprotective functions of PACAP in both in vitro and in vivo models. PACAP protects the neurons from death through both direct and indirect ways. PACAP inhibits caspase-3 through cAMP-PKA or MAP kinase-signaling pathways. Moreover, PACAP can stimulate astrocytes to release neuroprotective factors, such as interleukin-6 (IL-6). The present review will briefly summarize the recent studies and provide information for the future use in the clinic.

Top