Novel Atmospheric Biomolecule Ionization Technologies | OMICS International | Abstract
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
Open Access

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Review Article

Novel Atmospheric Biomolecule Ionization Technologies

Nelson G Chen1 , Jung-Lee Lin2 , Chen-Yi Wu2 , Kent J Gillig2 , Abdil Ozdemir3 * and Chung-Hsuan Chen2 *

1Department of Electric and Computer Engineering, National Chiao Tung University, Taipei, Taiwan

2Genomics Research Center, Academia Sinica, Taipei, Taiwan

3Department of Chemistry, Faculty of Arts and Sciences, Sakarya University, Sakarya, Turkey

*Corresponding Author:
Chung-Hsuan Chen
Distinguished Research Fellow and Director
The Genomics Research Center, Academia Sinica
128 Academia Road, Sec. 2, Nankang, Taipei 115, Taiwan
Tel: +886-2-2787-1200
Fax: +886-2-2789-9923
E-mail: [email protected]

Abdil Ozdemir
Department of Chemistry, Faculty of Arts and Sciences
Sakarya University, 54187 Esentepe, Sakarya, Turkey
E-mail: [email protected]

Received date: September 26, 2013; Accepted date: October 24, 2013; Published date: October 28, 2013

Citation: Chen NG, Lin JL, Wu CY, Gillig KJ, Ozdemir A, et al. (2013) Novel Atmospheric Biomolecule Ionization Technologies. J Anal Bioanal Tech S2:003. doi: 10.4172/2155-9872.S2-003

Copyright: © 2013 Chen NG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


In general, atmospheric ionization is defined as an ionization process outside of the mass spectrometer vacuum chamber. During the past two decades, several novel atmospheric ionization methods were developed. Nevertheless, they can be divided into two major categories. One is direct analysis at real time (DART) and the other is modifications on electrospray ionization (ESI). In addition, some methods are used to analyze samples directly without any pretreatments. Those methods are often called as ambient ionization methods. Many atmospheric ionization methods are also considered as ambient ionizations. DART and desorption electrospray ionization are examples. Nevertheless, most atmospheric ionization methods involve the need of high voltage outside of the mass spectrometer vacuum chamber. In this review, we will only briefly introduce most of the existing methods which need high voltages. Most effort will be placed on the newly developed novel methods which do not need high voltages. They include Ultrasound Ionization (UI), Triboelectric Spray Ionization (TeSI) and Kelvin spray ionization (KeSI). These ionization methods don’t need to have any external high voltage power supply for ionization. They have the advantages of very soft ionization to keep bio molecular ions more similar to the structures in solution phase. Some related mechanisms will also be discussed.