alexa

GET THE APP

Observation of Viable Nontypeable <em>Haemophilus Influenzae</em> Bacteria within Neutrophil Extracellular Traps in Clinical Samples from Chronic Otitis Media| Abstract
ISSN: 2161-119X

Otolaryngology: Open Access
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
  • Research Article   
  • Otolaryngology 2013, Vol 3(4): 145
  • DOI: 10.4172/2161-119X.1000145

Observation of Viable Nontypeable Haemophilus Influenzae Bacteria within Neutrophil Extracellular Traps in Clinical Samples from Chronic Otitis Media

Lauren B King1#, Bing Pang1#, Antonia C Perez1, Jennifer L Reimche1, Daniel J Kirse2, Amy S Whigham2, Adele K Evans2 and W Edward Swords1*
1Department of Microbiology and Immunology, Wake Forest School of Medicine, , North Carolina, USA
2Department of Otolaryngology, Wake Forest School of Medicine, , North Carolina, USA
#Contributed equally to this work
*Corresponding Author : W Edward Swords, Departments of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA, Tel: 336-713-5049, Email: [email protected]

Received Date: Sep 06, 2013 / Accepted Date: Oct 01, 2013 / Published Date: Oct 09, 2013

Abstract

Bacterial otitis media is an inherently inflammatory condition and often features an influx of neutrophils and other phagocytes into the middle-ear chamber. Neutrophils undergo a specific death pathway that results in formation of Neutrophil Extracellular Traps or “NETs”, which have been postulated as an antimicrobial defense mechanism that both mediates direct bacterial killing and facilitates phagocytic uptake and killing. However, we have shown that some mucosal pathogens within the airway including nontypeable Haemophilus influenzae survive within NETs in animal and in vitro models. In this report, we utilize exudate samples obtained from patients with chronic otitis media to show that nontypeable H. influenzae bacteria survive within NET structures within human patients.

Keywords: Neutrophil, Exudate, Bacteria, Otitis media

Citation: King LB, Pang B, Perez AC, Reimche JL, Kirse DJ, et al. (2013) Observation of Viable Nontypeable Haemophilus Influenzae Bacteria within Neutrophil Extracellular Traps in Clinical Samples from Chronic Otitis Media. Otolaryngology 3:145. Doi: 10.4172/2161-119X.1000145

Copyright: © 2013 King LB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Recommended Conferences

7th European Otolaryngology-ENT Surgery Conference

Vienna, Austria
Article Usage
  • Total views: 13215
  • [From(publication date): 11-2013 - Nov 30, 2021]
  • Breakdown by view type
  • HTML page views: 9163
  • PDF downloads: 4052
Top