Odor Identification Function Differs between Vascular Parkinson ism and Akinetic-Type Parkinson's Disease
|Mutsumi Iijima*, Mikio Osawa, Shinichiro Uchiyama and Kazuo Kitagawa|
|Department of Neurology, Tokyo Women’s Medical University School of Medicine, Japan|
|Corresponding Author :||Mutsumi Iijima
Department of Neurology
Tokyo Women’s Medical University School of Medicine
8-1 Kawada-cho Shinjuku, Tokyo 162–8666, Japan
E-mail: [email protected]
|Received January 08, 2016; Accepted January 22, 2016; Published January 29, 2016|
|Citation:Iijima M, Osawa M, Uchiyama S, Kitagawa K (2016) Odor Identification Function Differs between Vascular Parkinsonism and Akinetic-Type Parkinson’s Disease. J Alzheimers Dis Parkinsonism 6:207. doi: 10.4172/2161-0460.1000207|
|Copyright: © 2016 Iijima M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
|Related article at Pubmed, Scholar Google|
Objective: Main clinical features of vascular parkinsonism (VP) are rigidity, fixed face, and short stepping gait. VP remains difficult to diagnose based on clinical features from patients with Parkinson’s disease (PD) without rest tremor. Olfactory dysfunction is a non-motor symptom in idiopathic PD. We investigated whether olfactory function can distinguish VP from PD.
Method: Participants were comprised of 13 patients with VP, 40 non-demented patients with akinetic-type PD, and 40 age-matched controls. Olfactory function was examined using the Odor Stick Identification Test for Japanese (OSIT-J), which evaluates the detection of 12 odorants familiar to Japanese participants.
Results: Corrected odor identification scores in OSIT-J were 8.2 ± 1.5 (mean ± SD) points in patients with VP, 3.2 ± 2.5 in PD patients, and 7.1 ± 3.0 in normal subjects. These were significantly higher in VP than those in PD patients (p<0.001), but were not different from those in normal subjects.
Conclusion: The olfactory identification test is non-invasive, convenient, and useful to distinguish VP from PD as a screening test.