ISSN: 2161-119X

Otolaryngology: Open Access
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  • Research Article   
  • Otolaryngol (Sunnyvale) 2016, Vol 6(5): 266
  • DOI: 10.4172/2161-119X.1000266

Oral Carcinoma, HPV Infection, Arsenic Exposure-their Correlation in West Bengal, India

Pritha Pal* and Ajanta Halder
Department of Genetics, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan, 99 Sarat Bose Road, Kolkata, West Bengal, , India
*Corresponding Author : Pritha Pal, Research Scholar, Department of Genetics, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan, 99 Sarat Bose Road, Kolkata- 700026, West Bengal, India, Tel: +91 9903718344, Email: pritha.mcbt@gmail.com

Received Date: Sep 22, 2016 / Accepted Date: Oct 05, 2016 / Published Date: Oct 12, 2016

Abstract

Objective: The aim is to find out any possible correlation between HPV infection and oral carcinoma along with this metal toxicity. Methods: Ethical clearance for this study was obtained from the Ethics Committee of Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan. Patients attending our hospital were screened for the presence of oral premalignant and malignant lesions. The subjects were administered a standard questionnaire. The buccal swab and hair samples (107 cases and 50 controls) were collected after obtaining informed consent from all the corresponding subjects, and were analysed for detection of HPV 16 DNA and arsenic level analysis, respectively. Results: 22.5% of malignant samples showed the presence of HPV 16 DNA. 80% of cases showed their arsenic count above the safe limit (0.8 μg/g). Conclusion: A considerable percentage of malignant samples showed the presence of HPV16 DNA, indicating that there may be a correlation between HPV infection and oral malignancy in this population. A higher percentage of cases showing an elevated arsenic count states a possible link between arsenic toxicity and the development of this disease. However, a higher population size and statistical analysis are required for a proper conclusion.

Citation: Pal P, Halder A (2016) Oral Carcinoma, HPV Infection, Arsenic Exposure-their Correlation in West Bengal, India. Otolaryngol (Sunnyvale) 6:266. Doi: 10.4172/2161-119X.1000266

Copyright: © 2016 Pal P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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