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Oxic and Anoxic Metabolism of Steroids by Bacteria | OMICS International | Abstract
ISSN: 2155-6199

Journal of Bioremediation & Biodegradation
Open Access

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Special Issue Article

Oxic and Anoxic Metabolism of Steroids by Bacteria

Wael Ismail1 and Yin-Ru Chiang2*
1Biotechnology Program, College of Graduate Studies, Arabian Gulf University, Al-Manamah, Kingdom of Bahrain
2Microbiology Laboratory, Graduate Institute of Natural Products, College of Medicine, Chang-Gung University, Tao-Yuan, Taiwan
Corresponding Author : Dr. Yin-Ru Chiang
Microbiology Laboratory
Graduate Institute of Natural Products
College of Medicine, Chang-Gung University
259 Wen-Hwa 1st Road
Tao-Yuan, Taiwan
Tel: 886-3-2118800 ext. 5372
Fax: 886-3- 2118421
E-mail: [email protected]
Received Spetember 05, 2011; Accepted November 03, 2011; Published November 11, 2011
Citation: Sahli E, Tekeli O (2012) Evaluation of Retinal Nerve Fiber Layer Thickness with Spectral Domain Oct in Primary Open Angle Glaucoma and Ocular Hypertension. J Clin Exp Ophthalmol 3:247. doi: 10.4172/2155-6199.S1-001
Copyright: © 2011 Ismail W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Steroid compounds are produced by eukaryotes where they have a variety of chemical structures and play important physiological roles. Many bacteria are capable of transforming and completely degrading steroids under various growth conditions. The microbial metabolism of steroids has gained considerable interest due to its potential applications in industrial and environmental biotechnology. The oxic degradation pathways of steroids and some of the involved enzymes are well characterized. The key players in these pathways are oxygenases which depend on dioxygen as a co-substrate. On the contrary, much less is known about the mechanisms operating under anoxic conditions. Obviously, anoxic bacterial metabolism of steroids should proceed via oxygenase-independent reactions. So far, a few bacteria that can completely degrade steroids in the absence of oxygen were characterized. Surprisingly, all of them belong to denitrifying bacteria and utilize only nitrate as the alternative electron acceptor. Recent studies of anoxic metabolism of steroids using denitrifying bacteria revealed unique and interesting biochemical reactions and enzymes. Here we discuss the current understanding of the biochemistry and molecular biology of bacterial steroid metabolism under anoxic conditions. The aerobic metabolism of steroids is briefly presented for the sake of comparison. Future investigations on anoxic metabolism of steroids will unravel novel aspects of the regulation and evolution of catabolic pathways as well as unprecedented biocatalysts with useful applications in biotechnology.

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