alexa Oxidative Stress: A Comparison of Different Groups of P

Kidney Disorders and Clinical Practices
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Research Article

Oxidative Stress: A Comparison of Different Groups of Patients with Hepatitis-C in Hemodialysis Units

Da Silva NMO1*, Kalb AC2, Vidales-Braz BM2, Dos Santo DM2, Zanella RC3, Martinez EP2 and Martinez AMB2
1Institute Educar Brazil, Brazil
2Universidad Federal of Rio Grande, Brazil
3Hospital Pompéia, Brazil
*Corresponding Author : Da Silva NMO
Institute Educar Brasil, Faculdade Dom Bosco, Brazil
Tel: +55 53 3026-2099
E-mail: [email protected]
Received November 02, 2015; Accepted December 03, 2015; Published December 07, 2015
Citation: Da Silva NMO, Kalb AC, Vidales-Braz BM, Dos Santos DM, Zanella RC Martinez EP,Martinez AMB, et al. (2015) Oxidative Stress: A Comparison of Different Groups of Patients with Hepatitis-C in Hemodialysis Units. Kidney Disord Clin Pract 1: 104. doi:10.4172/kdc.1000104
Copyright: © 2015 Da Silva NMO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

There is a close relationship between patients undergoing hemodialysis (HD) treatment who are infected with hepatitis C virus (HCV) and oxidative stress (OS), which accelerates atherosclerotic processes and reduces the quality of life of the patients. Hemodialyzed patients have high morbidity and mortality. This study evaluated OS in patients undergoing HD against HCV infection. Four groups of patients (n=40 per group) were evaluated, including healthy patients (Group 1), patients on HD (Group 2), patients with HCV (Group 3) and patients with HCV on HD (Group 4). The groups were compared for the total antioxidant capacity (TAC) and the lipid peroxidation. The TAC decreased in the group 2 patients. In the analysis of the lipid peroxidation in erythrocytes, a significant increase (p<0.05) of the concentration of malondialdehyde (MDA) was observed in group 2 when compared to the group 3 patients. There was no significant difference (p>0.05) between the patients in groups 1, 3 and 4 and between group 2 when compared to group 4. The lipid peroxidation in the blood plasma demonstrates a significant association (p<0.05) in group 4. These results indicate that the HD process and HCV infection alter the peroxidation process by accelerating the process of atherosclerosis and reducing the quality of life of these patients.

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