Abstract

Diabetic neuropathy, a common complication of diabetes mellitus, is characterized by damage to the peripheral nerves. The pathogenesis of this condition is complex, involving metabolic abnormalities, oxidative stress, inflammation, and microvascular changes. Over time, there has been an improved understanding of the underlying mechanisms, leading to evolving management philosophies for diabetic neuropathy. This abstract highlights the changing approaches in the management of diabetic neuropathy, focusing on targeting the underlying pathogenesis. The key management strategies include optimizing glycemic control, addressing multifactorial risk factors, implementing antioxidant and anti-inflammatory therapies, utilizing neurotrophic factors and growth modulators, and providing symptomatic relief. These changing management philosophies aim to not only alleviate symptoms but also slow the progression of neuropathy and improve patient outcomes. The comprehensive management of diabetic neuropathy involves a multidisciplinary approach, incorporating lifestyle modifications, pharmacotherapy, and rehabilitative interventions. Further research and advancements in the understanding of the pathogenesis of diabetic neuropathy are essential to develop more targeted and effective treatments for this debilitating condition.