alexa Polyhydroxylated C60 Fullerenes Prevent Chondrocyte Catabolic Activity at Nanomolar Concentrations in Osteoarthritis | OMICS International

Journal of Osteoarthritis
Open Access

Like us on:

Announcement

Considering the opinion of the Editorial Board Members, the publisher has decided to merge Journal of Osteoarthritis to International Journal of Clinical Rheumatology. Therefore, all the existing and future readers, authors are hereby requested to visit the International Journal of Clinical Rheumatology now onwards.
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Polyhydroxylated C60 Fullerenes Prevent Chondrocyte Catabolic Activity at Nanomolar Concentrations in Osteoarthritis

Hirotaka Yoshioka1, Naoko Yui1, Kanaka Yatabe1, Hiroto Fujiya1, Haruki Musha1, Hisateru Niki2, Rie Karasawa3 and Kazuo Yudoh3*

1Department of Sports Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan

2Department of Orthopaedic Surgery, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8512, Japan

3Department of Frontier Medicine, Institute of Medical Science, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8512, Japan

*Corresponding Author:
Kazuo Yudoh
Department of Frontier Medicine
Institute of Medical Science
St. Marianna University School of Medicine
Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8512
Japan
Tel: +81-44-977-8111
Fax: +81-44-978-2036
E-mail: [email protected]

Received date: March 14, 2016; Accepted date: April 19, 2016; Published date: April 22, 2016

Citation: Yoshioka H, Yui N, Yatabe K, Fujiya H, Musha H, et al. (2016) Polyhydroxylated C60 Fullerenes Prevent Chondrocyte Catabolic Activity at Nanomolar Concentrations in Osteoarthritis. J Ost Arth 1:115.

Copyright: © 2016 Yoshioka H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Aim: Recently, numerous reports have demonstrated that oxidative stress and related chondrocyte aging may participate in the development of osteoarthritis (OA). To further understand the pathogenesis and degenerative process of OA, we have studied water-soluble polyhydroxylated C60 fullerene, a strong free radical scavenger, as an anti-oxidant.

Method: We examine the therapeutic effects of five types of water-soluble polyhydroxylated C60 fullerenes [C60(OH)10, C60(OH)24, C60(OH)26, C60(OH)36, C60(OH)44] on OA-related factor-induced catabolic responses in osteoarthritic chondrocytes. In the presence or absence of polyhydroxylated C60 fullerenes [C60(OH)10, C60(OH)24, C60(OH)26, C60(OH)36, C60(OH)44] (0.1, 1.0, 10.0 or 100 nM), human osteoarthritic chondrocytes were treated with IL-1β (10.0 ng/mL). After 24 hours incubation, chondrocyte activities were examined.

Results: Water-soluble polyhydroxylated C60 fullerenes inhibited OA-related catabolic responses (IL-1β- upregulation of cartilage degrading enzyme production and downregulation of proteoglycan production) in OA chondrocytes. C60(OH)10 C60(OH)24 and C60(OH)26 showed a stronger chondroprotective effect than C60(OH)36 or C60(OH)44.

Conclusion: Our findings indicate that polyhydroxylated C60 fullerenes, especially C60(OH)10 C60(OH)24 and C60(OH)26, may have a part to protect against OA related factor-mediated downregulation of osteoarthritic chondrocyte activities. These data may reveal a novel pathologic mechanism linking oxidative stress-induced development of OA.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version