Poor Sleep as a Precursor to Cognitive Decline in Down Syndrome : A Hypothesis*Corresponding Author: Fabian Fernandez PhD, Department of Physiology, Johns Hopkins University School of Medicine, Biophysics 203, 725 N. Wolfe St, Baltimore, MD 21205, USA, Tel: +1410955-6624, Fax: +14432870508, Email: [email protected]
Received Date: Aug 03, 2013 / Accepted Date: Aug 19, 2013 / Published Date: Aug 26, 2013
Citation: Fernandez F, Edgin JO (2013) Poor Sleep as a Precursor to Cognitive Decline in Down Syndrome: A Hypothesis. J Alzheimers Dis Parkinsonism 3:124.DOI: 10.4172/2161-0460.1000124
Copyright: © 2013 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
We propose that sleep disruption is a lever arm that influences how cognition emerges in development and then declines in response to Alzheimer disease in people with Down syndrome. Addressing sleep disruptions might be an overlooked way to improve cognitive outcomes in this population. This article is a contribution to a Special Issue on Down Syndrome curated by the editors of the Journal of Alzheimer’s Disease & Parkinsonism.